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Nicorandil

Known as: 2 Nicotinamidethyl Nitrate, 2 Nicotinamidoethyl Nitrate, 2-Nicotinamidethyl Nitrate 
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of… 
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (4)

AdancorDancorIkorelSG-75

Broader (5)

Anti-Arrhythmia AgentsAntihypertensive AgentsNiacinamideVasodilator Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2001
2001
Dual mechanism of action of nicorandil on rabbit corpus cavernosal smooth muscle tone
The potential of ATP-sensitive potassium channel openers (KCOs) for the treatment of male erectile dysfunction has recently been… 
2000
2000
Refractory coronary spasm relieved by intracoronary administration of nicorandil.
Two patients in whom coronary spasm was refractory to intracoronary injection of nitroglycerin were relieved by intracoronary… 
1999
1999
Dispersion-based reentry : mechanism of initiation of ventricular tachycardia in isolated rabbit hearts
EMMANUELLE ROBERT,1 A. GUY M. AYA,1 JEAN E. DE LA COUSSAYE,1 PASCALE PÉRAY,2 JEAN-MARIE JUAN,1 JOSEP BRUGADA,3 JEAN-MARC DAVY,4… 
1997
1997
Comparison of proarrhythmogenic effects of two potassium channel openers, levcromakalim (BRL 38227) and nicorandil (RP 46417): a high-resolution mapping study on rabbit heart.
This study was designed (a) to test and (b) to compare proarrhythmic effects of levcromakalim and nicorandil; and (c) determine… 
1992
1992
Comparison of KRN2391 with Nicorandil and Nifedipine on Canine Coronary Blood Flow: Antagonism by Glibenclamide
Summary: The mode of action of KRN2391 [N-cyano-N‘-(2-nitroxyethyl)-3-pyridinecarboximidamide monomethanesulfonate] in coronary… 
1984
1984
Effects of nicorandil on the membrane currents of rabbit sino-atrial node cells.
The effects of nicorandil (SG-75) (3-500 micrograms/ml) on the membrane potential and currents of the rabbit sino-atrial node… 
1983
1983
Mechanism of relaxant effects of nicorandil on the dog coronary artery.
In order to search into the mechanism of the relaxant effects of nicorandil, a new coronary vasodilator, on the dog coronary… 
1983
1983
Effects of Nicorandil and Its Interaction with Isoproterenol on Force of Contraction and Cyclic Nucleotide Levels of Canine Atrial Muscle: Comparison with Carbachol
Experiments were carried out on isolated canine right atria to investigate the effects of N-(2-hydroxyethyl)nicotinamide nitrate… 
1981
1981
Effects of 2-nicotinamidethyl nitrate (SG-75) and/or nitroglycerin on systemic hemodynamics and coronary blood flow in conscious dogs.
The effect of 2-nicotinamidethyl nitrate (SG-75), a newly synthesized nitroester, on hemodynamics and coronary circulation was… 
1980
1980
Effects of 2-nicotinamidethyl nitrate (SG-75), a new antianginal drug, on the cyclic AMP phosphodiesterase activity.
The effect of a potent coronary vasodilator, SG-75, on the purified cyclic AMP phosphodiesterase of the bovine heart was compared…