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Nickase

Known as: DNA Nicking Enzyme, Endonuclease I 
 
National Institutes of Health

Papers overview

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2018
2018
Abstract The use of paired Cas9 nickases instead of Cas9 nuclease drastically reduces off-target effects. Because both nickases… Expand
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2017
2017
Rapid and accurate bacterial detection methods are needed for clinical diagnostic, water, and food testing applications. The wide… Expand
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Highly Cited
2016
Highly Cited
2016
Solventogenic clostridia are important industrial microorganisms that produce various chemicals and fuels. Effective genetic… Expand
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2016
2016
The RNA-guided Cas9 nuclease is being widely employed to engineer the genomes of various cells and organisms. Despite the… Expand
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Highly Cited
2014
Highly Cited
2014
Engineered nucleases can be used to induce site-specific double-strand breaks (DSBs) in plant genomes. Thus, homologous… Expand
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2014
2014
The mammalian zygote-mediated CRISPR/Cas system can efficiently generate targeted genome-modified animals. However, this system… Expand
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2012
2012
Introduction bla OXA-48 is a globally emerging carbapenemase-encoding gene. The progenitor of bla OXA-48 appears to be a… Expand
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Highly Cited
2011
Highly Cited
2011
Gene targeting by homologous recombination (HR) can be induced by double-strand breaks (DSBs), however these breaks can be toxic… Expand
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1995
1995
The gene endA, encoding the periplasmic endonuclease I (EndoI) of Escherichia coli, was identified on a cloned chromosomal 1.5-kb… Expand
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1971
1971
DNA synthesis was studied in endonuclease I (endI)-deficient mutant cells, made permeable to nucleotides by a short treatment… Expand
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