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Nickase

Known as: DNA Nicking Enzyme, Endonuclease I 
National Institutes of Health

Related topics

Related topics

1 relation
Deoxyribonuclease I

Papers overview

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Highly Cited
2018
Highly Cited
2018
Paired D10A Cas9 nickases are sometimes more efficient than individual nucleases for gene disruption
Abstract The use of paired Cas9 nickases instead of Cas9 nuclease drastically reduces off-target effects. Because both nickases… 
2018
2018
Efficient genome editing by FACS enrichment of paired D10A Cas9 nickases coupled with fluorescent proteins
Targeted genome editing by clustered regularly interspaced short palindromic repeats (CRISPR-Cas9) raised concerns over off… 
2017
2017
Rapid Detection of Urinary Tract Infections via Bacterial Nuclease Activity.
2016
2016
Myostatin gene knockout mediated by Cas9-D10A nickase in chicken DF1 cells without off-target effect
Objective Based on rapid advancement of genetic modification techniques, genomic editing is expected to become the most efficient… 
2016
2016
Mapping the nicking efficiencies of nickase R.BbvCI for side-specific LNA-substituted substrates using rolling circle amplification
We used a novel asymmetric cleavage analysis method based on rolling circle amplification (RCA) to determine the effects of LNA… 
2016
2016
Construction of a new T-vector: Nickase (Nt.BspQI)-generated T-vector bearing a reddish-orange indicator gene
T-vectors are widely used for cloning the polymerase chain reaction (PCR) products. However, the low conversion efficiency of a… 
2015
2015
Completing the specificity swap: Single-stranded DNA recognition by F and R100 TraI relaxase domains.
2012
2012
Discovery of bla OXA-199, a Chromosome-Based bla OXA-48-Like Variant, in Shewanella xiamenensis
Introduction bla OXA-48 is a globally emerging carbapenemase-encoding gene. The progenitor of bla OXA-48 appears to be a… 
1995
1995
The periplasmic endonuclease I of Escherichia coli has amino-acid sequence homology to the extracellular DNases of Vibrio cholerae and Aeromonas hydrophila.
Highly Cited
1971
Highly Cited
1971
DNA synthesis in nucleotide-permeable Escherichia coli cells. I. Preparation and properties of ether-treated cells.
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