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Gene disruption by cell-penetrating peptide-mediated delivery of Cas9 protein and guide RNA.
RNA-guided endonucleases (RGENs) derived from the CRISPR/Cas system represent an efficient tool for genome editing. RGENs consist of two components: Cas9 protein and guide RNA. Plasmid-mediatedExpand
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PEST motif sequence regulating human NANOG for proteasomal degradation.
A number of transcriptional factors are required for pluripotency of stem cells. NANOG, a homeobox transcription factor, plays a critical role in regulating embryonic stem cell (ESC) pluripotency.Expand
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Lys-63-specific Deubiquitination of SDS3 by USP17 Regulates HDAC Activity*
SDS3 is a key component of the histone deacetylase (HDAC)-dependent Sin3A co-repressor complex, serving to maintain its HDAC activity. Here, we report both exogenous and endogenous functionalExpand
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The role of deubiquitinating enzymes in apoptosis
It has become apparent that ubiquitination plays a critical role in cell survival and cell death. In addition, deubiquitinating enzymes (DUBs) have been determined to be highly important regulatorsExpand
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Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations.
RNA-guided endonucleases (RGENs), which are based on the clustered, regularly interspaced, short palindromic repeat (CRISPR)-CRISPR-associated (Cas) system, have recently emerged as a simple andExpand
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Diverse roles of the scaffolding protein RanBPM.
Ran-binding protein microtubule-organizing center (RanBPM) appears to function as a scaffolding protein in several signal transduction pathways. RanBPM is a crucial component of multiproteinExpand
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Protein stability of mitochondrial superoxide dismutase SOD2 is regulated by USP36
SOD2 is a key mitochondrial antioxidant enzyme and its perturbation leads to oxidative cell death, which results in various disorders. In this study, we identified a deubiquitinating enzyme USP36Expand
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Hyaluronan Binding Motifs of USP17 and SDS3 Exhibit Anti-Tumor Activity
Background We previously reported that the USP17 deubiquitinating enzyme having hyaluronan binding motifs (HABMs) interacts with human SDS3 (suppressor of defective silencing 3) and specificallyExpand
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Stability and Function of Mammalian Lethal Giant Larvae-1 Oncoprotein Are Regulated by the Scaffolding Protein RanBPM*
The evolutionarily conserved lethal giant larvae (Lgl) tumor suppressor gene has an essential role in establishing apical-basal cell polarity, cell proliferation, differentiation, and tissueExpand
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Association study for single nucleotide polymorphisms in the CYP17A1 gene and polycystic ovary syndrome.
Women with polycystic ovary syndrome (PCOS) are characterized by excess androgen secretion and anovulatory infertility as a cause of follicular maturation arrest, and they are also associated withExpand
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