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Nicardipine

Known as: 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, methyl 2-(methyl(phenylmethyl)amino)ethyl ester, Nicardipinum, Nicardipino 
A synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain… Expand
National Institutes of Health

Related topics

Related topics

38 relations
10 ML Nicardipine hydrochloride 2.5 MG/ML Injection12 HR Nicardipine hydrochloride 60 MG Extended Release Oral Capsule [Cardene]Angina Pectoris, VariantAortic Valve Stenosis
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Narrower (13)

12 HR Nicardipine hydrochloride 45 MG Extended Release Oral Capsule200 ML Nicardipine hydrochloride 0.2 MG/ML InjectionCardeneCardene I.V.
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Broader (4)

Antihypertensive AgentsCalcium Channel BlockersVasodilator Agentspyridine carboxylate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The ECLIPSE Trials: Comparative Studies of Clevidipine to Nitroglycerin, Sodium Nitroprusside, and Nicardipine for Acute Hypertension Treatment in Cardiac Surgery Patients
BACKGROUND: Acute hypertension during cardiac surgery can be difficult to manage and may adversely affect patient outcomes… Expand
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Review
2005
Review
2005
Calcium channel blockers for primary Raynaud's phenomenon: a meta-analysis.
BACKGROUND To determine the efficacy of calcium channel blockers (CCBs) for primary Raynaud's phenomenon (RP). Primary outcomes… Expand
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Review
2003
Review
2003
Tacrolimus: a further update of its use in the management of organ transplantation.
UNLABELLED Extensive clinical use has confirmed that tacrolimus (Prograf) is a key option for immunosuppression after… Expand
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Highly Cited
1997
Highly Cited
1997
D1 Receptor Activation Enhances Evoked Discharge in Neostriatal Medium Spiny Neurons by Modulating an L-Type Ca2+ Conductance
Most in vitro studies of D1 dopaminergic modulation of excitability in neostriatal medium spiny neurons have revealed inhibitory… Expand
Highly Cited
1995
Highly Cited
1995
Medical complications of aneurysmal subarachnoid hemorrhage: a report of the multicenter, cooperative aneurysm study. Participants of the Multicenter Cooperative Aneurysm Study.
OBJECTIVES This report examines the frequency, type, and prognostic factors of medical (nonneurologic) complications after… Expand
Highly Cited
1993
Highly Cited
1993
Different types of calcium channels mediate central synaptic transmission
SYNAPTIC transmission is mediated by calcium entry through voltage-dependent calcium channels in presynaptic nerve terminals1,2… Expand
Highly Cited
1991
Highly Cited
1991
Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes.
To determine whether endothelin-1 (ET-1) induces hypertrophy of cardiomyocytes, the effects of ET-1 on the expression of muscle… Expand
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Highly Cited
1990
Highly Cited
1990
Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.
In previous papers we demonstrated that cyclosporin A (CsA) was specifically oxidized in rabbit and human liver by cytochrome P… Expand
Highly Cited
1989
Highly Cited
1989
Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM…
The calcium channel blocker verapamil has been shown to reverse multidrug resistance (T. Tsuruo et al., Cancer Res. 41: 1967-1972… Expand
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Highly Cited
1984
Highly Cited
1984
Voltage‐Dependent Block of Calcium Channel Current in the Calf Cardiac Purkinje Fiber by Dihydropyridine Calcium Channel Antagonists
We have investigated the mechanisms of blockade of calcium channel current by the dihydropyridines, e.g. nisoldipine… Expand
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