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Neutrophil Cytosolic Factor 2

Known as: 67 kDa Neutrophil Oxidase Factor, Neutrophil Cytosolic Factor 2 (65kD, Chronic Granulomatous Disease, Autosomal 2), Neutrophil NADPH Oxidase Factor 2 
Neutrophil cytosol factor 2 (526 aa, ~60 kDa) is encoded by the human NCF2 gene. This protein plays a role in the generation of superoxide in… 
National Institutes of Health

Related topics

Related topics

10 relations
Antigen PresentationAntigen ProcessingFormyl Peptide Receptor 1 Signaling PathwayImmune System Processes

Broader (1)

neutrophil cytosol factor 67K

Papers overview

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Highly Cited
2005
Highly Cited
2005
Physical Inactivity Increases Oxidative Stress, Endothelial Dysfunction, and Atherosclerosis
Objective—Sedentary lifestyle is associated with increased cardiovascular events. The underlying molecular mechanisms are… 
Review
2004
Review
2004
Giant atrial septal aneurysm simulating a right atrial tumour
A 75 year old man was admitted to the hospital for elective coronary artery bypass grafting (CABG). He had a history of stable… 
Highly Cited
2003
Highly Cited
2003
Increased Superoxide Generation Is Associated With Pulmonary Hypertension in Fetal Lambs: A Role for NADPH Oxidase
Abstract— Ligation of the ductus arteriosus in utero produces pulmonary hypertension and vascular remodeling in fetal and newborn… 
Highly Cited
2002
Highly Cited
2002
The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils.
In a previous study, the S100A8/A9 protein, a Ca2+- and arachidonic acid-binding protein, abundant in neutrophil cytosol, was… 
Highly Cited
2001
Highly Cited
2001
PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox
The production of reactive oxygen species (ROS) by neutrophils has a vital role in defence against a range of infectious agents… 
Highly Cited
2000
Highly Cited
2000
Structure of the TPR domain of p67phox in complex with Rac.GTP.
Highly Cited
1994
Highly Cited
1994
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity.
Rho and Rac, two members of the Ras superfamily of guanosine triphosphate (GTP)-binding proteins, regulate a variety of signal… 
Highly Cited
1994
Highly Cited
1994
Activation of NADPH oxidase involves the dissociation of p21rac from its inhibitory GDP/GTP exchange protein (rhoGDI) followed by its translocation to the plasma membrane.
Activation of the NADPH oxidase of phagocytes involves the small GTP-binding protein p21rac. In this paper we report that… 
Highly Cited
1994
Highly Cited
1994
Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558.
Highly Cited
1993
Highly Cited
1993
p40phox, a third cytosolic component of the activation complex of the NADPH oxidase to contain src homology 3 domains.
The NADPH oxidase generates superoxide in phagocytic cells. It is important for immunity and its deficiency leads to chronic… 
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