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Neutrophil Cytosolic Factor 2

Known as: 67 kDa Neutrophil Oxidase Factor, Neutrophil Cytosolic Factor 2 (65kD, Chronic Granulomatous Disease, Autosomal 2), Neutrophil NADPH Oxidase Factor 2 
Neutrophil cytosol factor 2 (526 aa, ~60 kDa) is encoded by the human NCF2 gene. This protein plays a role in the generation of superoxide in… 
National Institutes of Health

Related topics

Related topics

10 relations
Antigen PresentationAntigen ProcessingFormyl Peptide Receptor 1 Signaling PathwayImmune System Processes

Broader (1)

neutrophil cytosol factor 67K

Papers overview

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2008
2008
Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase.
2007
2007
Leu505 of Nox2 is crucial for optimal p67phox‐dependent activation of the flavocytochrome b558 during phagocytic NADPH oxidase assembly
The role of Leu505 of Nox2 on the NADPH oxidase activation process was investigated. An X‐CGD PLB‐985 cell line expressing the… 
2004
2004
Dynamic influences on a high-affinity, high-specificity interaction involving the C-terminal SH3 domain of p67phox.
An analysis of the backbone dynamics of the C-terminal Src homology 3 (SH3) domain of p67(phox), p67(phox)SH3(C), in complex with… 
1997
1997
Expression of NADPH oxidase is induced by all-trans retinoic acid but not by phorbol myristate acetate and 1,25 dihydroxyvitamin D3 in the human promyelocytic cell line NB4
Human promyelocytic cells, NB4, differentiate into neutrophils in response to all-trans retinoic acid (ATRA). It has recently… 
1997
1997
Deficiency of p67phox, p47phox or gp91phox in chronic granulomatous disease does not impair leucocyte chemotaxis or motility
Chronic granulomatous disease (CGD) is a syndrome characterized by failure of the NADPH oxidase of phagocytes that generates… 
1997
1997
SH3 domain-mediated interactions involving the phox components of the NADPH oxidase
Abstract.Objective and Design: To derive a model describing the SH3 domain-mediated assembly of the activated NADPH oxidase… 
Highly Cited
1996
Highly Cited
1996
Topological organization of the cytosolic activating complex of the superoxide-generating NADPH-oxidase. Pinpointing the sites of interaction between p47phoz, p67phox and p40phox using the two-hybrid…
Highly Cited
1995
Highly Cited
1995
A 68-kDa Kinase and NADPH Oxidase Component p67 Are Targets for Cdc42Hs and Rac1 in Neutrophils (*)
Cdc42Hs and Rac1 are members of the Ras superfamily of small molecular weight (p21) GTP binding proteins. Cdc42Hs induces… 
1995
1995
Okadaic acid induces both augmentation and inhibition of opsonized zymosan-stimulated superoxide production by differentiated HL-60 cells. Possible involvement of dephosphorylation of a cytosolic 21K…
Highly Cited
1993
Highly Cited
1993
Production of recombinant cytochrome b558 allows reconstitution of the phagocyte NADPH oxidase solely from recombinant proteins.
Phagocytic white blood cells contain a multicomponent oxidase that generates microbicidal products by catalyzing electron… 
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