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Neurofibromatosis Type 1 Protein

Known as: Neurofibromin 1, neurofibromatosis type 1 protein/gene, NF1-GAP-Related Protein 
The 250 kD neurofibromin product, encoded by the tumor suppressor NF1 gene, is thought to restrict cell proliferation by functioning as a RAS… 
National Institutes of Health

Related topics

Related topics

16 relations
GTPase-Activating ProteinsIn BloodNF1 geneNeurofibromatoses

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7
Circular RNAs (circRNAs) are significantly dysregulated in various cancer types. However, the roles and mechanisms of circRNAs in… 
Highly Cited
2015
Highly Cited
2015
Sirolimus for progressive neurofibromatosis type 1-associated plexiform neurofibromas: a neurofibromatosis Clinical Trials Consortium phase II study.
BACKGROUND Plexiform neurofibromas (PNs) are benign peripheral nerve sheath tumors that arise in one-third of individuals with… 
Highly Cited
2015
Highly Cited
2015
Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium
Cells use phagocytosis and macropinocytosis to internalise bulk material, which in phagotrophic organisms supplies the nutrients… 
Highly Cited
2014
Highly Cited
2014
The Hippo Pathway Is Activated and Is a Causal Mechanism for Adipogenesis in Arrhythmogenic Cardiomyopathy
Rationale: Mutations in the intercalated disc proteins, such as plakophilin 2 (PKP2), cause arrhythmogenic cardiomyopathy (AC… 
Highly Cited
1996
Highly Cited
1996
Identification of NF1 mutations in both alleles of a dermal neurofibroma
A hallmark clinical feature of neurofibromatosis 1 (NF1) is multiple dermal neurofibromas, benign tumours that typically appear… 
Review
1996
Review
1996
Control of ras activation.
Ras proteins are active when bound to GTP and inactive when bound to GDP: the activation state of Ras proteins is regulated by… 
Highly Cited
1993
Highly Cited
1993
Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro
THE Ras proteins are key regulators of the growth of eukaryotic cells, but their direct target enzymes, or 'effectors', are… 
Highly Cited
1993
Highly Cited
1993
A conserved alternative splice in the von Recklinghausen neurofibromatosis (NF1) gene produces two neurofibromin isoforms, both of which have GTPase-activating protein activity
Sequence analysis has shown significant homology between the catalytic regions of the mammalian ras GTPase-activating protein… 
Highly Cited
1993
Highly Cited
1993
Characterization of full‐length neurofibromin: tubulin inhibits Ras GAP activity.
Full‐length neurofibromin is a GTPase activating protein (GAP) for the Ras proto‐oncogene product. Regulation of neurofibromin… 
Highly Cited
1992
Highly Cited
1992
Somatic mutations in the neurofibromatosis 1 gene in human tumors
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