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Neurofibromatosis Type 1 Protein

Known as: Neurofibromin 1, neurofibromatosis type 1 protein/gene, NF1-GAP-Related Protein 
The 250 kD neurofibromin product, encoded by the tumor suppressor NF1 gene, is thought to restrict cell proliferation by functioning as a RAS… 
National Institutes of Health

Related topics

Related topics

16 relations
GTPase-Activating ProteinsIn BloodNF1 geneNeurofibromatoses

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Regulation of the Ras‐GTPase activating protein neurofibromin by C‐tail phosphorylation: implications for protein kinase C/Ras/extracellular signal‐regulated kinase 1/2 pathway signaling and neuronal…
PKC, Ras, and ERK1/2 signaling is pivotal to differentiation along the neuronal cell lineage. One crucial protein that may play a… 
Highly Cited
2003
Highly Cited
2003
Neurofibromatosis Type I Tumor Suppressor Neurofibromin Regulates Neuronal Differentiation via Its GTPase-activating Protein Function toward Ras*
Neurofibromin, the neurofibromatosis type 1 (NF1) gene product, contains a central domain homologous to a family of proteins… 
Highly Cited
1998
Highly Cited
1998
A Role for Cyclin-Dependent Kinase(s) in the Modulation of Fast Anterograde Axonal Transport: Effects Defined by Olomoucine and the APC Tumor Suppressor Protein
Proteins that interact with both cytoskeletal and membrane components are candidates to modulate membrane trafficking. The tumor… 
Highly Cited
1996
Highly Cited
1996
Increased neurofibromatosis 1 gene expression in astrocytic tumors: positive regulation by p21-ras.
The neurofibromatosis 1 (NF1) gene has been implicated in astrocyte growth regulation in several studies. To determine whether… 
Highly Cited
1995
Highly Cited
1995
Neurofibromatosis 1 (NF1) mRNAs expressed in the central nervous system are differentially spliced in the 5' part of the gene.
The neurofibromatosis 1 gene seems to play essential roles at several different stages of life. During embryogenesis, it is… 
Highly Cited
1995
Highly Cited
1995
Different structural requirements within the switch II region of the Ras protein for interactions with specific downstream targets.
Ras proteins function through the formation of specific complexes with Raf-1, B-raf, PI-3 kinase and RalGDS. These interactions… 
Highly Cited
1995
Highly Cited
1995
Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin.
The rate of GTP hydrolysis on p21ras is accelerated by approximately 10(5) times by the catalytic domains of GTPase-activating… 
Highly Cited
1994
Highly Cited
1994
Differential expression and tissue distribution of type I and type II neurofibromins during mouse fetal development.
Mutations in the NF1 gene may cause developmental abnormalities and the formation of a variety of tumors of neural crest origin… 
Highly Cited
1993
Highly Cited
1993
Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming…
Highly Cited
1993
Highly Cited
1993
Mouse neurofibromatosis type 1 cDNA sequence reveals high degree of conservation of both coding and non-coding mRNA segments.
To identify evolutionary conserved domains and facilitate the recognition of potentially significant mutations in NF1 patients or… 
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