NF1 gene

Known as: NEUROFIBROMIN 1, Watson disease, nf 1 Genes 
Tumor suppressor genes located on the long arm of human chromosome 17 in the region 17q11.2. Mutation of these genes is thought to cause… (More)
National Institutes of Health

Related topics

Related topics

35 relations
Atypical NeurofibromaCardiac NeurofibromaCellular NeurofibromaCervical Malignant Peripheral Nerve Sheath Tumor
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
The NF1 tumor suppressor critically regulates TSC2 and mTOR.
Loss-of-function mutations in the NF1 tumor suppressor gene underlie the familial cancer syndrome neurofibromatosis type I (NF1… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Optic nerve glioma in mice requires astrocyte Nf1 gene inactivation and Nf1 brain heterozygosity.
Whereas biallelic neurofibromatosis 1 (NF1) inactivation is observed in NF1-associated gliomas, astrocyte-restricted Nf1… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Astrocyte-specific inactivation of the neurofibromatosis 1 gene (NF1) is insufficient for astrocytoma formation.
Individuals with the neurofibromatosis 1 (NF1) inherited tumor syndrome develop low-grade gliomas (astrocytomas) at an increased… (More)
  • figure 2
  • figure 3
  • figure 4
  • figure 5
  • figure 6
Is this relevant?
Review
2000
Review
2000
NF1 gene and neurofibromatosis 1.
Neurofibromatosis 1 (NF1), also known as von Recklinghausen disease, is an autosomal dominant condition caused by mutations of… (More)
  • table 1
  • table 2
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Genomic organization of the neurofibromatosis 1 gene (NF1).
Neurofibromatosis 1 maps to chromosome band 17q11.2, and the NF1 locus has been partially characterized. Even though the full… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
Human neurofibromatosis type 1 is a dominant disease caused by the inheritance of a mutant allele of the NF1 gene. In order to… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor.
Neurofibromatosis 2 (NF2) is a dominantly inherited disorder characterized by the occurrence of bilateral vestibular schwannomas… (More)
Is this relevant?
Highly Cited
1991
Highly Cited
1991
cDNA cloning of the type 1 neurofibromatosis gene: complete sequence of the NF1 gene product.
Von Recklinghausen neurofibromatosis, or type 1 neurofibromatosis (NF1), is a common autosomal dominant disorder characterized by… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 5
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Type 1 neurofibromatosis gene: identification of a large transcript disrupted in three NF1 patients.
Von Recklinghausen neurofibromatosis (NF1) is a common autosomal dominant disorder characterized by abnormalities in multiple… (More)
Is this relevant?
Highly Cited
1990
Highly Cited
1990
Deletions and a translocation interrupt a cloned gene at the neurofibromatosis type 1 locus
Three new neurofibromatosis type 1 (NF1) mutations have been detected and characterized. Pulsed-field gel and Southern blot… (More)
Is this relevant?