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Neurofibrillary degeneration (morphologic abnormality)

Known as: NFT, Neurofibrillary tangles, Tangle, Neurofibrillary 
Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules… 
National Institutes of Health

Related topics

Related topics

19 relations
Alzheimer Disease, Familial Early-Onset, With Coexisting Amyloid And Prion PathologyAlzheimer disease, familial, type 3Alzheimer's DiseaseDiffuse Neurofibrillary Tangles with Calcification

Broader (1)

Nerve Degeneration

Narrower (1)

paired helical filament

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing.
Aggregation and cleavage are two hallmarks of Tau pathology in Alzheimer disease (AD), and abnormal fragmentation of Tau is… 
Review
2002
Review
2002
Alzheimer’s disease and the basal forebrain cholinergic system: relations to β-amyloid peptides, cognition, and treatment strategies
Highly Cited
1994
Highly Cited
1994
Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau
Highly Cited
1993
Highly Cited
1993
Abnormal Alzheimer‐like phosphorylation of tau‐protein by cyclin‐dependent kinases cdk2 and cdk5
Highly Cited
1992
Highly Cited
1992
Glycogen synthase kinase-3 induces Alzheimer's disease-like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
Review
1989
Review
1989
Excitatory amino acids and Alzheimer's disease
Highly Cited
1988
Highly Cited
1988
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease
Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits… 
Highly Cited
1988
Highly Cited
1988
Microtubule-associated protein MAP2 shares a microtubule binding motif with tau protein
The microtubule-associated protein MAP2 is a prominent large-sized component of purified brain microtubules that, like the 36- to… 
Highly Cited
1988
Highly Cited
1988
Epitopes that span the tau molecule are shared with paired helical filaments
Highly Cited
1987
Highly Cited
1987
Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease.
The formation of clusters of altered axons and dendrites surrounding extracellular deposits of amyloid filaments (neuritic… 
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