paired helical filament

Known as: PHF 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
In 1906, Alzheimer described the clinical and neuropathological characteristics of the disease that was subsequently named after… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Alzheimer's disease (AD) is characterized neuropathologically by intracellular neurofibrillary tangles (NFTs) formed of tau-based… (More)
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The microtubule-associated protein tau is a family of six isoforms that becomes abnormally hyperphosphorylated and accumulates in… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The major protein subunit of the paired helical filaments (PHF) of Alzheimer disease (AD) is the microtubule-associated protein… (More)
Is this relevant?
Highly Cited
1993
Highly Cited
1993
The Alzheimer's disease paired helical filament (PHF), after digestion with Pronase, retains its characteristic morphological… (More)
Is this relevant?
Highly Cited
1988
Highly Cited
1988
The paired helical filament, the principal constituent of the neurofibrillary tangles characteristic of Alzheimer disease, is… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Screening of cDNA libraries prepared from the frontal cortex of an Alzheimer disease patient and from fetal human brain has led… (More)
Is this relevant?
Highly Cited
1987
Highly Cited
1987
Paired helical filaments (PHF), which constitute a distinct type of pathological neuronal fiber, are the principal constituent of… (More)
Is this relevant?
Highly Cited
1986
Highly Cited
1986
Microtubule-associated protein tau was purified from bovine brain microtubules by either (1) phosphocellulose chromatography, (2… (More)
Is this relevant?
Highly Cited
1986
Highly Cited
1986
The detailed protein composition of the paired helical filaments (PHF) that accumulate in human neurons in aging and Alzheimer… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?