Negative Regulation of S Phase

Known as: S Phase Arrest 
S Phase Arrest consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the cell cycle stage… (More)
National Institutes of Health

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Cell NucleusCell ProliferationIntercellular Communication ProcessMitogens
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Papers overview

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2014
2014
Anticarcinogenic effects of products of heat-processed ginsenoside Re, a major constituent of ginseng berry, on human gastric cancer cells.
Ginsenoside Re is a triol type triterpene glycoside and is abundantly present in ginseng berry. In the present study, we verified… (More)
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2011
2011
Xanthoxyletin, a coumarin induces S phase arrest and apoptosis in human gastric adenocarcinoma SGC-7901 cells.
This study was conducted to explore the novel anticancer compounds from Chinese herbs. During the process of screening, to… (More)
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2010
2010
Evodiamine induces caspase-dependent apoptosis and S phase arrest in human colon lovo cells.
Evodiamine, one of the major bioactive components derived from Wu-Chu-Yu, a long-standing Chinese herb, was reported to possess… (More)
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2008
2008
Silence of ClC-3 chloride channel inhibits cell proliferation and the cell cycle via G/S phase arrest in rat basilar arterial smooth muscle cells.
OBJECTIVES Previously, we have found that the ClC-3 chloride channel is involved in endothelin-1 (ET-1)-induced rat aortic smooth… (More)
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2007
2007
Erlotinib, an effective epidermal growth factor receptor tyrosine kinase inhibitor, induces p27KIP1 up-regulation and nuclear translocation in association with cell growth inhibition and G1/S phase…
Erlotinib, a small-molecule epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, has been shown to have potent… (More)
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2006
2006
Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells.
Notch is an ancient cell signaling system that regulates cell fate specification, stem cell maintenance and initiation of… (More)
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Highly Cited
2005
Highly Cited
2005
Resveratrol causes Cdc2-tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells.
Resveratrol is one of the most extensively studied cancer chemopreventive agents; however, its mechanisms of action are not… (More)
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2004
2004
Enhanced tumor cell radiosensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin.
PURPOSE Because of the potential for affecting multiple signaling pathways, inhibition of Hsp90 may provide a strategy for… (More)
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2004
2004
Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block.
The cyclin-dependent kinase inhibitor p21, a major transcriptional target of the tumor suppressor p53, plays a critical role in… (More)
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2001
2001
p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest.
We investigated the role of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) in cell cycle regulation during… (More)
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