Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells
- Zhiwei Wang, Yuxiang Zhang, Yiwei Li, Sanjeev Banerjee, J. Liao, F. Sarkar
- BiologyMolecular Cancer Therapeutics
- 1 March 2006
It is suggested that Notch-1 down-regulation, especially by genistein, could be a novel therapeutic approach for the treatment of pancreatic cancer.
Down-regulation of notch-1 inhibits invasion by inactivation of nuclear factor-kappaB, vascular endothelial growth factor, and matrix metalloproteinase-9 in pancreatic cancer cells.
- Zhiwei Wang, Sanjeev Banerjee, Yiwei Li, K. Rahman, Yuxiang Zhang, F. Sarkar
- BiologyCancer Research
- 1 March 2006
The down-regulation of Notch-1 could be an effective approach for the down- regulation and inactivation of NF-kappaB and its target genes, such as MMP-9 and VEGF expression, resulting in the inhibition of invasion and metastasis.
Retracted: Notch‐1 down‐regulation by curcumin is associated with the inhibition of cell growth and the induction of apoptosis in pancreatic cancer cells
- Zhiwei Wang, Yuxiang Zhang, Sanjeev Banerjee, Yiwei Li, F. Sarkar
- BiologyCancer
- 1 June 2006
No studies have determined whether the down‐regulation of Notch‐1 signaling, resulting in the inactivation of NF‐κB activity, contributes to curcumin‐induced cell growth inhibition and apoptosis in pancreatic cancer cells.
Retracted: Inhibition of nuclear factor κb activity by genistein is mediated via Notch‐1 signaling pathway in pancreatic cancer cells
- Zhiwei Wang, Yuxiang Zhang, Sanjeev Banerjee, Yiwei Li, F. Sarkar
- Biology
- 15 April 2006
This article has been retracted at the request of the editor‐in‐chief and author because of a lack of original research.
Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells.
- Zhiwei Wang, Yuxiang Zhang, Sanjeev Banerjee, Yiwei Li, F. Sarkar
- BiologyInternational Journal of Cancer
- 2006
The inhibition of Notch-1 and NF-kappaB activity and their cross talk provides a novel mechanism by which genistein inhibits cell growth and induces apoptotic processes in pancreatic cancer cells.
Molecular evidence for increased antitumor activity of gemcitabine by genistein in vitro and in vivo using an orthotopic model of pancreatic cancer.
- Sanjeev Banerjee, Yuxiang Zhang, F. Sarkar
- Biology, ChemistryCancer Research
- 1 October 2005
Genistein in combination with gemcitabine is much more effective as an antitumor agent compared with either agent alone in the authors' orthotopic tumor model and a specific target, such as NF-kappaB, was inactivated in genistein-treated animal tumors and that gem citabine-induced activation of NF- kappaB was completely inhibited in animal tumors treated with genisteIn and gemcitABine.
Retracted: In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer
- Sanjeev Banerjee, Yuxiang Zhang, F. Sarkar
- MedicineInternational Journal of Cancer
- 15 February 2007
This article has been retracted at the request of the editor‐in‐chief and author because of a lack of original research.
Src family kinase inhibitor PP2 efficiently inhibits cervical cancer cell proliferation through down-regulating phospho-Src-Y416 and phospho-EGFR-Y1173
- L. Kong, Zhihong Deng, Haiying Shen, Yuxiang Zhang
- BiologyMolecular and Cellular Biochemistry
- 1 February 2011
The results indicate that Src pathway and EGFR pathway play different roles in the proliferation of cervical cancer cells and PP2 efficiently reduces cervical cancer cell proliferation by reduction of both Src and EG FR activity.
Regulation of pancreatic stellate cell activation by Notch3
- Ha-Eon Song, Yuxiang Zhang
- Biology, MedicineBMC Cancer
- 5 January 2018
Notch3 inhibition in PaSCs can inhibit the activation, proliferation and migration of Pa SCs and reduce the PaSC-induced pro-tumorigenic effect, which is a potential novel therapeutic option for patients with PDAC.
Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway.
- L. Kong, G. Schäfer, H. Bu, Yong Zhang, Yuxiang Zhang, H. Klocker
- BiologyCarcinogenesis
- 1 April 2012
Detailed expression analysis in PC tissue and mechanism studies suggest that lamin A/C proteins are positively involved in malignant behavior of PC cells through the PI3K/AKT/PTEN pathway.
...
...