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Negative Elongation Factor C/D

Known as: NELFCD, Negative Elongation Factor Proteins C and D, NELF-C/D 
Negative elongation factor C/D (590 aa, ~66 kDa) is encoded by the human NELFCD gene. This protein is involved in transcriptional pausing.
National Institutes of Health

Related topics

Related topics

6 relations
Genes, RegulatorNELFCD geneTranscription ElongationTranscription Repressor/Corepressor

Papers overview

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2019
2019
Single-Cell Profiling Defines Transcriptomic Signatures Specific to Tumor-Reactive versus Virus-Responsive CD4+ T Cells
2018
2018
NELFCD and CTSZ loci are associated with jaundice-stage progression in primary biliary cholangitis in the Japanese population
Approximately 10–20% of patients with primary biliary cholangitis (PBC) progress to jaundice stage regardless of treatment with… 
2018
2018
Overexpression of NELFCD promotes colorectal cancer cells proliferation, migration, and invasion
Purpose Negative elongation factor complex member C/D (NELFCD), mapped to chromosome 20q13.32, has been found to be significantly… 
2012
2012
Trihydrophobin 1 Phosphorylation by c-Src Regulates MAPK/ERK Signaling and Cell Migration
c-Src activates Ras-MAPK/ERK signaling pathway and regulates cell migration, while trihydrophobin 1 (TH1) inhibits MAPK/ERK… 
2010
2010
Negative role of trihydrophobin 1 in breast cancer growth and migration
Trihydrophobin 1 (TH1) is a member of the negative elongation factor complex, which is involved in transcriptional pausing… 
2010
2010
Trihydrophobin 1 attenuates androgen signal transduction through promoting androgen receptor degradation
The androgen‐signaling pathway plays critical roles in normal prostate development, benign prostatic hyperplasia, established… 
2009
2009
Trihydrophobin 1 Interacts with PAK1 and Regulates ERK/MAPK Activation and Cell Migration*
The Rac1/Cdc42 effector, p21-activated kinase (PAK), is activated by various signaling cascades, including receptor-tyrosine… 
2007
2007
Ubiquitin‐dependent proteolysis of trihydrophobin 1 (TH1) by the human papilloma virus E6‐associated protein (E6‐AP)
Human Papilloma virus E6‐associated protein (E6‐AP), which is known as an E3 ubiquitin ligase, mediates ubiquitination and… 
2006
2006
Expression and distribution of trihydrophobin 1 in postnatal developing mouse testis
The human trihydrophobin 1 (TH1) is a highly conserved and widely expressed protein. It is clear that TH1 serves as a new… 
2004
2004
Trihydrophobin 1 Is a New Negative Regulator of A-Raf Kinase*
Our previous work indicated that instead of binding to B-Raf or C-Raf, trihydrophobin 1 (TH1) specifically binds to A-Raf kinase… 
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