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Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
The recommended treatment for patients with chronic hepatitis C, pegylated interferon-α (PEG-IFN-α) plus ribavirin (RBV), does not provide sustained virologic response (SVR) in all patients. WeExpand
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Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development
Chondrocyte hypertrophy followed by cartilage matrix degradation and vascular invasion, characterized by expression of type X collagen (COL10A1), matrix metalloproteinase-13 (MMP-13) and vascularExpand
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SORL1 Is Genetically Associated with Late-Onset Alzheimer’s Disease in Japanese, Koreans and Caucasians
To discover susceptibility genes of late-onset Alzheimer’s disease (LOAD), we conducted a 3-stage genome-wide association study (GWAS) using three populations: Japanese from the Japanese GeneticExpand
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  • Open Access
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074Expand
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  • Open Access
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.
For the identification of susceptibility loci for primary biliary cirrhosis (PBC), a genome-wide association study (GWAS) was performed in 963 Japanese individuals (487 PBC cases and 476 healthyExpand
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Evaluating the performance of Affymetrix SNP Array 6.0 platform with 400 Japanese individuals
BackgroundWith improvements in genotyping technologies, genome-wide association studies with hundreds of thousands of SNPs allow the identification of candidate genetic loci for multifactorialExpand
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The Q223R polymorphism in LEPR is associated with obesity in Pacific Islanders
Various Pacific Island populations have experienced a marked increase in the prevalence of obesity in past decades. This study examined the association of a promoter polymorphism of the leptin geneExpand
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Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Narcolepsy (hypocretin deficiency), a sleep disorder characterized by sleepiness, cataplexy and rapid eye movement (REM) sleep abnormalities, is tightly associated with HLA-DRB1*1501 (M17378) andExpand
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Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population
To identify susceptibility genes for endometriosis in Japanese women, genome-wide association (GWA) analysis was performed using two case–control cohorts genotyped with the Affymetrix Mapping 500KExpand
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Induction of IFN-λ3 as an additional effect of nucleotide, not nucleoside, analogues: a new potential target for HBV infection
Objective The clinical significance of polymorphisms in the interleukin-28B gene encoding interferon (IFN)-λ3, which has antiviral effects, is known in chronic HCV but not in HBV infection. Thus, weExpand
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  • Open Access