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NVP-AEW541

National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
2012
2012
Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity.
AIM To assess the effects of a novel type 1 insulin-like growth factor receptor (IGF-1R) inhibitor, NVP-AEW541, on cell… 
2012
2012
Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
Insulin-like growth factor-1 receptor (IGF1R) signalling is implicated in resistance to trastuzumab. However, the benefit of co… 
2012
2012
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition
We have previously demonstrated an increased DNA copy number and expression of IGF1R to be associated with poor outcome in Wilms… 
2012
2012
Treatment of breast cancer cells by IGF1R tyrosine kinase inhibitor combined with conventional systemic drugs.
AIM Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell growth and survival of cancer… 
2011
2011
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
2008
2008
Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells.
The aberrant expression of the epidermal growth factor receptor (EGFR) has been reported in a wide range of epithelial tumours… 
Highly Cited
2007
Highly Cited
2007
Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma.
Highly Cited
2006
Highly Cited
2006
Insulin-like growth factor receptor I targeting in epithelial ovarian cancer.
2006
2006
Effects of insulin-like growth factor-1 receptor inhibition in mesothelioma. Thoracic Surgery Directors Association Resident Research Award.
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