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NVP-AEW541

 
National Institutes of Health

Papers overview

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2012
2012
BackgroundAberrant expression and activation of the IGF-IR have been reported in a variety of human cancers and have been… Expand
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2010
2010
AIM To investigate in vitro treatment with NVP-AEW541, a small molecule inhibitor of insulin-like growth factor-1 receptor (IGF… Expand
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2010
2010
IGF-1 receptor signaling contributes to the growth of many solid tumors, including glioblastoma. This study analyzed the… Expand
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Highly Cited
2008
Highly Cited
2008
A subset of gastrointestinal stromal tumors (GISTs) lack gain-of-function mutations in c-KIT and PDGFRalpha. These so-called wild… Expand
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Highly Cited
2008
Highly Cited
2008
The insulin-like growth factor-I receptor (IGF-IR) is frequently overexpressed and constitutively activated in pancreatic cancer… Expand
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2008
2008
Multiple myeloma (MM) is a B-cell malignancy characterized by accumulation of monoclonal plasma cells in the bone marrow (BM… Expand
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2007
2007
Insulin-like growth factor-I (IGF-I) and its receptor (IGF-IR) have been implicated in the pathophysiology of many human cancers… Expand
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2006
2006
PURPOSE Signaling through insulin-like growth factor I receptor (IGF-IR) is important for growth and survival of many tumor types… Expand
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Highly Cited
2005
Highly Cited
2005
Identification of new drugs is strongly needed for sarcomas. Insulin-like growth factor-I receptor (IGF-IR) was found to provide… Expand
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Highly Cited
2004
Highly Cited
2004
IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth… Expand
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