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NVP-AEW541

National Institutes of Health

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Broader (2)

PyrimidinesPyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Optimisation of a 5-[3-phenyl-(2-cyclic-ether)-methyl-ether]-4-aminopyrrolopyrimidine series of IGF-1R inhibitors.
2012
2012
Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
Insulin-like growth factor-1 receptor (IGF1R) signalling is implicated in resistance to trastuzumab. However, the benefit of co… 
2012
2012
Treatment of breast cancer cells by IGF1R tyrosine kinase inhibitor combined with conventional systemic drugs.
AIM Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell growth and survival of cancer… 
2011
2011
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression
2009
2009
Sensitivity of breast cancer cell lines to the novel insulin-like growth factor-1 receptor (IGF-1R) inhibitor NVP-AEW541 is dependent on the level of IRS-1 expression.
2008
2008
Co-targeting the EGFR and IGF-IR with anti-EGFR monoclonal antibody ICR62 and the IGF-IR tyrosine kinase inhibitor NVP-AEW541 in colorectal cancer cells.
The aberrant expression of the epidermal growth factor receptor (EGFR) has been reported in a wide range of epithelial tumours… 
2008
2008
Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
Insulin-like growth factor-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal… 
Highly Cited
2007
Highly Cited
2007
Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma.
Highly Cited
2006
Highly Cited
2006
Insulin-like growth factor receptor I targeting in epithelial ovarian cancer.
2006
2006
Effects of insulin-like growth factor-1 receptor inhibition in mesothelioma. Thoracic Surgery Directors Association Resident Research Award.
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