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NVP-AEW541

National Institutes of Health

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Papers overview

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2016
2016
Abstract 5077: The insulin-like growth factor-2 (IGF-2): A potential therapeutic target for triple-negative breast cancer metastasis
Introduction: Triple-negative breast cancers (TNBC) occur in 15-17% of patients, yet this subtype accounts for almost half of all… 
2014
2014
Erratum to: Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
2014
2014
Study of the Selectivity of Insulin-Like Growth Factor-1 Receptor (IGF1R) Inhibitors
The insulin-like growth factor-1 receptor (IGF1R) is a drug target for oncology, and many studies are ongoing to identify… 
2013
2013
Synergistic growth inhibition of human pancreatic cancer cells following treatment with a combination of ErbB family blocker afatinib and IGF-IR inhibitor NVP-AEW541
Aberrant expression the insulin-like growth factor receptor (IGF-IR) has been reported in a variety of human cancers and has been… 
2012
2012
Treatment of breast cancer cells by IGF1R tyrosine kinase inhibitor combined with conventional systemic drugs.
AIM Insulin-like growth factor-1 receptor (IGF1R) is a tyrosine kinase receptor mediating cell growth and survival of cancer… 
2011
2011
THE REGULATION AND FUNCTION OF THE OVARIAN-DERIVED INSULIN-LIKE GROWTH FACTOR SYSTEM IN ZEBRAFISH (Danio rerio)
Insulin-like growth factors (IGF) are known paracrine/autocrine regulators of ovarian development in teleosts. Initial studies… 
2011
2011
Abstract 630: Responses of human pancreatic cancer cells to treatment with insulin-like growth factor receptor (IGF-IR) tyrosine kinase inhibitor NVP-AEW541 alone and in combination with anti-EGFR…
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Aberrant expression and activation of growth factor… 
2008
2008
Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
Insulin-like growth factor-I receptor (IGF-IR) signaling is required for carcinogenicity and proliferation of gastrointestinal… 
2006
2006
In vivo and In vitro Neuroblastoma Cells Activity by NVP-AEW 541 Has an Antitumor Effect on Down-Regulation of Insulin-Like Growth Factor I Receptor
Purpose: Signaling through insulin-like growth factor I receptor (IGF-IR) is important for growth and survival of many tumor… 
2004
2004
NVP-AEW541: A Selective Small Molecule IGF-1R Tyrosine Kinase Inhibitor Is Active Against Multiple Myeloma and Other Hematologic Neoplasias and Solid Tumors.
We have shown that insulin-like growth factors (IGFs) and their receptor IGF-1R play critical roles in proliferation, survival… 
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