NVP ABE171

Known as: 4-(8-benzo(1,2,5)oxadiazol-5-yl-(1,7)naphthyridin-6-yl)benzoic acid, NVP-ABE171, NVPABE171 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED There is a need to improve treatments for metastatic breast cancer. Here, we show the activation of the… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are… (More)
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Highly Cited
2011
Highly Cited
2011
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast… (More)
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Highly Cited
2010
Highly Cited
2010
The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to… (More)
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Highly Cited
2008
Highly Cited
2008
Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the… (More)
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Highly Cited
2008
Highly Cited
2008
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor… (More)
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Highly Cited
2006
Highly Cited
2006
NMDA-type glutamate receptors (NMDARs) contribute to many forms of long-term potentiation (LTP) and long-term depression (LTD… (More)
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Highly Cited
2004
Highly Cited
2004
IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth… (More)
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Highly Cited
2002
Highly Cited
2002
OBJECTIVE Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the… (More)
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