NVP ABE171

Known as: 4-(8-benzo(1,2,5)oxadiazol-5-yl-(1,7)naphthyridin-6-yl)benzoic acid, NVP-ABE171, NVPABE171 
 
National Institutes of Health

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2 relations

Broader (2)

NaphthyridinesOxadiazoles

Papers overview

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Highly Cited
2012
Highly Cited
2012
Identification and characterization of NVP-BKM120, an orally available pan-class I PI3-kinase inhibitor.
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
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Highly Cited
2012
Highly Cited
2012
Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer.
UNLABELLED There is a need to improve treatments for metastatic breast cancer. Here, we show the activation of the… (More)
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Highly Cited
2012
Highly Cited
2012
FGFR genetic alterations predict for sensitivity to NVP-BGJ398, a selective pan-FGFR inhibitor.
UNLABELLED Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are… (More)
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Highly Cited
2011
Highly Cited
2011
Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth…
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast… (More)
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Highly Cited
2010
Highly Cited
2010
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma.
The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to… (More)
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Highly Cited
2008
Highly Cited
2008
NVP-BEZ 235 , a Dual PI 3 K / mTOR Inhibitor , Prevents PI 3 K Signaling and Inhibits the Growth of Cancer Cells with Activating PI 3 K Mutations
Phosphatidylinositol-3-kinase (PI3K) pathway deregulation is a common event in human cancer, either through inactivation of the… (More)
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Highly Cited
2008
Highly Cited
2008
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
We describe the biological properties of NVP-AUY922, a novel resorcinylic isoxazole amide heat shock protein 90 (HSP90) inhibitor… (More)
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Highly Cited
2006
Highly Cited
2006
Distinct roles for Ras-guanine nucleotide-releasing factor 1 (Ras-GRF1) and Ras-GRF2 in the induction of long-term potentiation and long-term depression.
NMDA-type glutamate receptors (NMDARs) contribute to many forms of long-term potentiation (LTP) and long-term depression (LTD… (More)
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Highly Cited
2004
Highly Cited
2004
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
IGF-IR-mediated signaling promotes survival, anchorage-independent growth, and oncogenic transformation, as well as tumor growth… (More)
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Highly Cited
2002
Highly Cited
2002
Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes.
OBJECTIVE Glucagon-like peptide-1 (GLP-1) has been proposed as a new treatment modality for type 2 diabetes. To circumvent the… (More)
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