NT-3 Growth Factor Receptor, Human

Known as: Trk-C, NT3 Growth Factor Receptor, NT-3 Growth Factor Receptor 
NT-3 growth factor receptor (839 aa, ~94 kDa) is encoded by the human NTRK3 gene. This protein is involved in ligand binding, tyrosine… (More)
National Institutes of Health

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22 relations
Cell Differentiation processCell ProliferationEnzyme GeneImmunoglobulin C2-set Domain
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Papers overview

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Review
2006
Review
2006
Neurotrophin-regulated signalling pathways.
Neurotrophins are a family of closely related proteins that were identified initially as survival factors for sensory and… (More)
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Highly Cited
1998
Highly Cited
1998
Characterization of Neurotrophin and Trk Receptor Functions in Developing Sensory Ganglia Direct NT-3 Activation of TrkB Neurons In Vivo
Spinal sensory ganglia have been shown to contain neuronal subpopulations with different functions and neurotrophin dependencies… (More)
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Highly Cited
1997
Highly Cited
1997
BDNF and NT-4/5 prevent atrophy of rat rubrospinal neurons after cervical axotomy, stimulate GAP-43 and Talpha1-tubulin mRNA expression, and promote axonal regeneration.
Rubrospinal neurons (RSNs) undergo a marked atrophy in the second week after cervical axotomy. This delayed atrophy is… (More)
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Highly Cited
1996
Highly Cited
1996
Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75 ngfr , TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues
The steady-state mRNA levels of the four neurotrophic factors of nerve growth factor (NGF), brain-dervied neurotrophic factor… (More)
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Review
1994
Review
1994
The Trk family of neurotrophin receptors.
Accumulating evidence indicates that the Trk family of tyrosine protein kinase receptors, Trk (also known as TrkA), TrkB, and… (More)
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Highly Cited
1994
Highly Cited
1994
Severe sensory and sympathetic deficits in mice lacking neurotrophin-3
DURING development, neurotrophins help shape the nervous system by regulating neuronal survival and differentiation. Neurotrophin… (More)
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Highly Cited
1994
Highly Cited
1994
Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.
The neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4/5 (NT-4/5) were compared… (More)
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Highly Cited
1994
Highly Cited
1994
Disruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements
THE trkC gene1,2 is expressed throughout the mammalian nervous system3-5 and encodes a series of tyrosine protein kinase isoforms… (More)
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Highly Cited
1993
Highly Cited
1993
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF.
To investigate the possibility of neurotrophins acting directly on hippocampal neurons, we first examined expression of the trk… (More)
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Highly Cited
1991
Highly Cited
1991
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3.
We report the isolation and molecular characterization of trkC, a new member of the trk family of tyrosine protein kinase genes… (More)
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