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The p75 Neurotrophin Receptor Negatively Modulates Dendrite Complexity and Spine Density in Hippocampal Neurons
The correlation between functional and structural neuronal plasticity is by now well documented. However, the molecular mechanisms translating patterns of neuronal activity into specific changes inExpand
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Brain‐derived Neurotrophic Factor is a Survival Factor for Cultured Rat Cerebellar Granule Neurons and Protects them Against Glutamate‐induced Neurotoxicity
We have studied the effects of different neurotrophins on the survival and proliferation of rat cerebellar granule cells in culture. These neurons express trkB and trkC, the putative neuronalExpand
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A crucial role for neurotrophin-3 in oligodendrocyte development
THE neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 promote the survival of subpopulations of vertebrate neurons in vitro, but so far onlyExpand
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The zinc finger protein NRIF interacts with the neurotrophin receptor p75(NTR) and participates in programmed cell death.
NRIF (neurotrophin receptor interacting factor) is a ubiquitously expressed zinc finger protein of the Krüppel family which interacts with the neurotrophin receptor p75(NTR). The interaction wasExpand
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The neurotrophin receptor p75(NTR): novel functions and implications for diseases of the nervous system.
Neurotrophins have long been known to promote the survival and differentiation of vertebrate neurons. However, these growth factors can also induce cell death through the p75 neurotrophin receptorExpand
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Complete ablation of the neurotrophin receptor p75NTR causes defects both in the nervous and the vascular system
We identified a protein isoform of the common neurotrophin receptor p75NTR that arises from alternative splicing of exon III in the p75NTR locus. Because this protein is left intact in the previouslyExpand
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A splice variant of the neurotrophin receptor trkB with increased specificity for brain‐derived neurotrophic factor.
The trkB gene codes for a receptor tyrosine kinase, which is essential for the development of the peripheral nervous system. This receptor can be activated by three different neurotrophins: BDNF,Expand
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Reversal of cocaine‐conditioned place preference and mesocorticolimbic Zif268 expression by social interaction in rats
Little is known how social interaction, if offered as an alternative to drug consumption, affects neural circuits involved in drug reinforcement and substance dependence. Conditioned place preferenceExpand
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Complete Deletion of the Neurotrophin Receptor p75NTRLeads to Long-Lasting Increases in the Number of Basal Forebrain Cholinergic Neurons
Cholinergic neurons innervating cortical structures are among the most affected neuronal populations in Alzheimer's disease. In rodents, they express high levels of the neurotrophin receptor p75NTR.Expand
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Binding of brain-derived neurotrophic factor to the nerve growth factor receptor
The neurotrophic proteins BDNF and NGF are related in their primary structures, and both have high- and low-affinity receptors on their responsive neurons. In this study, we investigate the extent toExpand
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