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NSC 663284

Known as: NSC-663284, NSC663284 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

QuinolonesQuinones

Papers overview

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2017
2017
Identification of the quinolinedione inhibitor binding site in Cdc25 phosphatase B through docking and molecular dynamics simulations
Cdc25 phosphatase B, a potential target for cancer therapy, is inhibited by a series of quinones. The binding site and mode of… 
2013
2013
NSC 663284 Inhibits SHP-2
There-fore, the finding and developing of the specific inhibitorsthat target protein phosphatase or kinases are essential… 
2013
2013
Abstract 956: Role of the cell cycle regulator LZTS1 in docetaxel resistance of prostate cancer cells and overcoming the docetaxel resistance by cell cycle pharmacological inhibitors.
Background: Docetaxel is the standard treatment for metastatic castration-resistant prostate cancer (CRPC) since 2004 and overall… 
2005
2005
Redox regulation of Cdc25B by novel cell active quinolinediones
660 Cdc25 dual specificity phosphatases are overexpressed in many human tumors and have oncogenic properties. Although several… 
2004
2004
NAD(P)H:Quinone Oxidoreductase-1-Dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors
Cdc25 dual-specificity phosphatases coordinate cell cycle progression and cellular signaling. Consequently, Cdc25 inhibitors… 
2004
2004
NAD ( P ) H : Quinone Oxidoreductase-1-Dependent and-Independent Cytotoxicity of Potent Quinone Cdc 25 Phosphatase Inhibitors
Cdc25 dual-specificity phosphatases coordinate cell cycle progression and cellular signaling. Consequently, Cdc25 inhibitors… 
Highly Cited
2004
Highly Cited
2004
Down-regulation of Survivin in Nitric Oxide-induced Cell Growth Inhibition and Apoptosis of the Human Lung Carcinoma Cells*
Survivin is expressed in most tumor cells and has been associated with both anti-apoptosis and mitotic progression. However, the… 
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