Skip to search formSkip to main contentSkip to account menu

NSC 109555

Known as: NSC-109555, NSC109555 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

diacetyldiphenylurea bisguanylhydrazone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Abstract 3409: Inhibition of checkpoint kinase 2 enhances sensitivity of pancreatic adenocarcinoma cells to Gemcitabine.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Checkpoint kinase 1/2 (Chk1/2) plays pivotal… 
2010
2010
Hypomethylating Agents Correct Subcellular Localization of FOXO3a and (re)Establish Expression of Its Transcriptional Targets In AML and MDS- Cells
Abstract 2173 Background: We previously found deregulation of DNA-damage response (DDR) signaling in MDS and AML, notably the… 
Highly Cited
2009
Highly Cited
2009
Cellular Inhibition of Checkpoint Kinase 2 (Chk2) and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor PV1019 [7-Nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone…
Chk2 is a checkpoint kinase involved in the ataxia telangiectasia mutated pathway, which is activated by genomic instability and… 
2008
2008
Crystal structure of checkpoint kinase 2 in complex with NSC 109555, a potent and selective inhibitor
Checkpoint kinase 2 (Chk2), a ser/thr kinase involved in the ATM‐Chk2 checkpoint pathway, is activated by genomic instability and… 
Highly Cited
2007
Highly Cited
2007
Identification of a Bis-guanylhydrazone [4,4′-Diacetyldiphenylurea-bis(guanylhydrazone); NSC 109555] as a Novel Chemotype for Inhibition of Chk2 Kinase
Chk2 is a protein kinase involved in the ATM-dependent checkpoint pathway (http://discover.nci.nih.gov/mim). This pathway is… 
2007
2007
Identification of a bis-guanylhydrazone ( NSC 109555 ) as a novel chemotype for inhibition of Chk 2 kinase
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)