Discovery of cyanovirin-N, a novel human immunodeficiency virus-inactivating protein that binds viral surface envelope glycoprotein gp120: potential applications to microbicide development
- M. Boyd, K. Gustafson, L. Henderson
- BiologyAntimicrobial Agents and Chemotherapy
- 1 July 1997
The novel 11-kDa virucidal protein, named cyanovirin-N (CV-N), is isolated and sequenced from cultures of the cyanobacterium (blue-green alga) Nostoc ellipsosporum and is highly resistant to physicochemical denaturation, further enhancing its potential as an anti-HIV microbicide.
Ulosantoin, a potent insecticide from the sponge Ulosa ruetzleri
- B. Vanwagenen, R. Larsen, J. Cardellina, D. Randazzo, Z. Lidert, C. Swithenbank
- Biology
- 1993
Ulosantoin (2), a phosphorylated hydantoin, has been isolated from organic soluble extracts of the sponge Ulosa ruetzleri and found to exhibit marked insecticidal activity against tobacco hornworm…
Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity.
- D. Kong, E. Park, G. Melillo
- Biology, ChemistryCancer Research
- 1 October 2005
It is shown that it is possible to identify small molecules that inhibit HIF-1 DNA binding to endogenous promoters and echinomycin, a small-molecule known to bind DNA in a sequence-specific fashion, was investigated.
The guttiferones, HIV-inhibitory benzophenones from Symphonia globulifera, Garcinia livingstonei, Garcinia ovalifolia and Clusia rosea
- K. Gustafson, J. Blunt, M. Boyd
- Biology
- 1992
The calanolides, a novel HIV-inhibitory class of coumarin derivatives from the tropical rainforest tree, Calophyllum lanigerum.
- Y. Kashman, K. Gustafson, M. Boyd
- Chemistry, BiologyJournal of Medicinal Chemistry
- 24 July 1992
Calanolide A was active not only against the AZT-resistant G-9106 strain of HIV-1 but also against the pyridinone-resistant A17 strain, which was of particular interest since the A17 virus is highly resistant to previously known HIV- 1 specific, non-nucleoside RT inhibitors.
Maculosin, a host-specific phytotoxin for spotted knapweed from Alternaria alternata.
- A. Stierle, J. Cardellina, G. Strobel
- BiologyProceedings of the National Academy of Sciences…
- 1 November 1988
Several diketopiperazines have been isolated from liquid cultures of Alternaria alternata, the causal agent of black leaf blight of spotted knapweed, and maculosin is a host-specific phytotoxin from a weed pathogen.
Circulins A and B. Novel human immunodeficiency virus (HIV)-inhibitory macrocyclic peptides from the tropical tree Chassalia parvifolia.
- K. Gustafson, R. Sowder, M. Boyd
- Biology
- 1 October 1994
New pyranocoumarins isolated from Calophyllum lanigerum and Calophyllum teysmannii.
During a chemotaxonomic survey of Calophyllum extracts present in the National Cancer Institute's natural product repository, four new pyranocoumarins were isolated from extracts of C. lanigerum var.…
A nonpromoting phorbol from the samoan medicinal plant Homalanthus nutans inhibits cell killing by HIV-1.
- K. Gustafson, J. Cardellina, J. Beutler
- BiologyJournal of Medicinal Chemistry
- 29 May 1992
Extracts of Homalanthus nutans, a plant used in Samoan herbal medicine, exhibited potent activity in an in vitro, tetrazolium-based assay which detects the inhibition of the cytopathic effects of…
Seaweed dermatitis: structure of lyngbyatoxin A.
- J. Cardellina, F. Marner, R. Moore
- ChemistryScience
- 13 April 1979
A highly inflammatory and vesicatory substance, lyngbyatoxin A, has been isolated from the lipid extract of a Hawaiian shallow-water variety of Lyngbya majuscula Gomont; its gross structure was…
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