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NRXN2 gene

Known as: Neurexin 2 Gene, NRXN2, neurexin 2 
This gene may play a role in cell adhesion.
National Institutes of Health

Related topics

Related topics

6 relations
Cell AdhesionLigand BindingNeurexin-2, humanSignal Transduction
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Heterozygous Deletion of α-Neurexin I or α-Neurexin II Results in Behaviors Relevant to Autism and Schizophrenia
The neurexins are a family of presynaptic cell adhesion molecules. Human genetic studies have found heterozygous deletions… Expand
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2015
2015
Genetic targeting of NRXN2 in mice unveils role in excitatory cortical synapse function and social behaviors
Human genetics has identified rare copy number variations and deleterious mutations for all neurexin genes (NRXN1-3) in patients… Expand
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Highly Cited
2014
Highly Cited
2014
SMN deficiency alters Nrxn2 expression and splicing in zebrafish and mouse models of spinal muscular atrophy.
Spinal muscular atrophy (SMA) is a progressive neurodegenerative disease affecting lower motor neurons. SMA is caused by… Expand
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Highly Cited
2014
Highly Cited
2014
Deletion of α-neurexin II results in autism-related behaviors in mice
Autism is a common and frequently disabling neurodevelopmental disorder with a strong genetic basis. Human genetic studies have… Expand
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Highly Cited
2013
Highly Cited
2013
Rare exonic deletions implicate the synaptic organizer Gephyrin (GPHN) in risk for autism, schizophrenia and seizures.
The GPHN gene codes for gephyrin, a key scaffolding protein in the neuronal postsynaptic membrane, responsible for the clustering… Expand
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Highly Cited
2012
Highly Cited
2012
Rare deletions at the neurexin 3 locus in autism spectrum disorder.
The three members of the human neurexin gene family, neurexin 1 (NRXN1), neurexin 2 (NRXN2), and neurexin 3 (NRXN3), encode… Expand
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Highly Cited
2011
Highly Cited
2011
Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia
Growing genetic evidence is converging in favor of common pathogenic mechanisms for autism spectrum disorders (ASD), intellectual… Expand
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Highly Cited
2009
Highly Cited
2009
Disruption of the neurexin 1 gene is associated with schizophrenia.
Deletions within the neurexin 1 gene (NRXN1; 2p16.3) are associated with autism and have also been reported in two families with… Expand
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Highly Cited
2009
Highly Cited
2009
LAD-1/variant syndrome is caused by mutations in FERMT3.
Leukocyte adhesion deficiency-1/variant (LAD1v) syndrome presents early in life and manifests by infections without pus formation… Expand
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Highly Cited
2002
Highly Cited
2002
Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.
The neurexins are neuronal proteins that function as cell adhesion molecules during synaptogenesis and in intercellular signaling… Expand
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