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NR1I2 wt Allele

Known as: PAR, SAR, PXR 
Human NR1I2 wild-type allele is located within 3q12-q13.3 and is approximately 38 kb in length. This allele, which encodes nuclear receptor subfamily… 
National Institutes of Health

Related topics

Related topics

15 relations
Biologic DevelopmentCell Differentiation processCell ProliferationHomeostasis

Broader (1)

NR1I2 gene

Papers overview

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Highly Cited
2013
Highly Cited
2013
Both PHYTOCHROME RAPIDLY REGULATED1 (PAR1) and PAR2 Promote Seedling Photomorphogenesis in Multiple Light Signaling Pathways1[C][W][OPEN]
Both PAR1 and PAR2, encoding bHLH transcription factors, enhance seedling deetiolation under far-red, red, and blue light… 
2011
2011
Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.
Highly Cited
2009
Highly Cited
2009
Identification of pregnane X receptor ligands using time-resolved fluorescence resonance energy transfer and quantitative high-throughput screening.
The human pregnane X nuclear receptor (PXR) is a xenobiotic-regulated receptor that is activated by a range of diverse chemicals… 
Highly Cited
2008
Highly Cited
2008
Computational Discovery of Novel Low Micromolar Human Pregnane X Receptor Antagonists
Very few antagonists have been identified for the human pregnane X receptor (PXR). These molecules may be of use for modulating… 
Highly Cited
2006
Highly Cited
2006
Regulation and Binding of Pregnane X Receptor by Nuclear Receptor Corepressor Silencing Mediator of Retinoid and Thyroid Hormone Receptors (SMRT)
The pregnane X receptor (PXR) is an orphan nuclear receptor predominantly expressed in liver and intestine. PXR coordinates… 
Highly Cited
2004
Highly Cited
2004
Identification of amino acids in rat pregnane X receptor that determine species-specific activation.
The pregnane X receptor (PXR) is a nuclear receptor significantly involved in the transcriptional regulation of drug-metabolizing… 
2004
2004
Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene.
Cytochrome P450 3A4 (CYP3A4) is the major cytochrome P450 present in adult human liver and is involved in the metabolism of over… 
Highly Cited
2003
Highly Cited
2003
Transgenic mouse models of human CYP3A4 gene regulation.
CYP3A4, the predominant but variably expressed cytochrome P450 of adult human liver, is subject to multifaceted constitutive… 
Highly Cited
2002
Highly Cited
2002
A Cell-Based Reporter Gene Assay for Determining Induction of CYP3A4 in a High-Volume System
Assessing the inducibility of CYP3A4 by various xenobiotics can predict potential drug interactions. In the present investigation… 
Highly Cited
2002
Highly Cited
2002
Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.
Endocannabinoid stucture-activity relationships (SAR) indicate that the CB1 receptor recognizes ethanolamides whose fatty acid… 
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