NR1I2 wt Allele

Known as: PAR, SAR, PXR 
Human NR1I2 wild-type allele is located within 3q12-q13.3 and is approximately 38 kb in length. This allele, which encodes nuclear receptor subfamily… (More)
National Institutes of Health

Papers overview

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Review
2005
Review
2005
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… (More)
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Highly Cited
2005
Highly Cited
2005
Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis… (More)
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Highly Cited
2002
Highly Cited
2002
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2002
Highly Cited
2002
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… (More)
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Review
2002
Review
2002
The nuclear pregnane X receptor (PXR; NR1I2) is an important component of the body's adaptive defense mechanism against toxic… (More)
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Highly Cited
2000
Highly Cited
2000
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR… (More)
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Highly Cited
2000
Highly Cited
2000
Transcription of genes encoding cytochrome P450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural… (More)
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Highly Cited
1998
Highly Cited
1998
The cytochrome P-450 monooxygenase 3A4 (CYP3A4) is responsible for the oxidative metabolism of a wide variety of xenobiotics… (More)
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Highly Cited
1998
Highly Cited
1998
Steroid hormones exert profound effects on differentiation, development, and homeostasis in higher eukaryotes through… (More)
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Highly Cited
1998
Highly Cited
1998
An important requirement for physiologic homeostasis is the detoxification and removal of endogenous hormones and xenobiotic… (More)
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