NR1I2 gene

Known as: PAR, NUCLEAR RECEPTOR SUBFAMILY 1, GROUP I, MEMBER 2, PXR 
This gene is involved in the regulation of genes that affect steroid and xenobiotic metabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1977-2018
020406019772018

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND & AIMS Liver X receptor (LXR) is known to promote hepatic lipogenesis by activating the lipogenic transcriptional… (More)
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Highly Cited
2007
Highly Cited
2007
The liver X receptors (LXRalpha and beta) are nuclear receptors that coordinate carbohydrate and lipid metabolism. Insight into… (More)
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Highly Cited
2006
Highly Cited
2006
We report an extensive study of variability in genes encoding proteins that are believed to be involved in the action and… (More)
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Highly Cited
2004
Highly Cited
2004
To gain insight on the expression of pregnane X receptor (PXR), we analyzed PXR.1 and PXR alternatively spliced transcripts in a… (More)
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Highly Cited
2003
Highly Cited
2003
CYP2B6 plays an important role in the metabolism of a variety of structurally unrelated xenobiotics, including the anticancer… (More)
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Highly Cited
2003
Highly Cited
2003
The orphan nuclear receptor pregnane X receptor (PXR) is essential for the transcriptional regulation of hepatic xenobiotic… (More)
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Highly Cited
2003
Highly Cited
2003
The nuclear xenobiotic receptor PXR is activated by a wide variety of clinically used drugs and serves as a master regulator of… (More)
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Highly Cited
2002
Highly Cited
2002
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2001
Highly Cited
2001
Cytochromes P450 (P450s) are involved in the oxidative metabolism of a plethora of structurally unrelated compounds, including… (More)
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Highly Cited
2000
Highly Cited
2000
Transcription of genes encoding cytochrome P450 3A (CYP3A) monooxygenases is induced by a variety of xenobiotics and natural… (More)
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