Transgenic mouse models of human CYP3A4 gene regulation.

  title={Transgenic mouse models of human CYP3A4 gene regulation.},
  author={Graham R. Robertson and Jacqueline Field and Bryan Goodwin and Sandra Bierach and Minh Tran and Anne M. Lehnert and Christopher Liddle},
  journal={Molecular pharmacology},
  volume={64 1},
CYP3A4, the predominant but variably expressed cytochrome P450 of adult human liver, is subject to multifaceted constitutive regulation as well as transcriptional induction by a variety of structurally unrelated xenobiotics. Using transient transfections in HepG2 cells, we previously demonstrated the existence of a potent xenobiotic-responsive enhancer module located between - 7.2 and - 7.8 kilobases upstream of the CYP3A4 transcription start site. Induction is mediated by interaction of… 

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