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NR1H4 protein, human

Known as: farnesoid X receptor NR1H4, human, bile acid receptor NR1H4, human, Retinoid X Receptor-Interacting Protein 14 
Bile acid receptor (486 aa, ~56 kDa) is encoded by the human NR1H4 gene. This protein is involved in both ligand-mediated gene expression and the… 
National Institutes of Health

Related topics

Related topics

21 relations
Biologic DevelopmentCell Differentiation processCell NucleusCell Proliferation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
TUDCA: An Agonist of the Bile Acid Receptor GPBAR1/TGR5 With Anti‐Inflammatory Effects in Microglial Cells
Bile acids are steroid acids found in the bile of mammals. The bile acid conjugate tauroursodeoxycholic acid (TUDCA) is… 
Highly Cited
2016
Highly Cited
2016
Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice
Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of… 
Highly Cited
2012
Highly Cited
2012
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis.
BACKGROUND & AIMS Cholestasis is a liver disorder characterized by impaired bile flow, reduction of bile acids (BAs) in the… 
Highly Cited
2012
Highly Cited
2012
Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine in mice
Farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily and is the primary bile acid receptor. We previously… 
Highly Cited
2011
Highly Cited
2011
Bile Acid Signaling in Liver Metabolism and Diseases
Obesity, diabetes, and metabolic syndromes are increasingly recognized as health concerns worldwide. Overnutrition and insulin… 
Highly Cited
2006
Highly Cited
2006
Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration
Liver mass depends on one or more unidentified humoral signals that drive regeneration when liver functional capacity is… 
Highly Cited
2006
Highly Cited
2006
Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) in mice.
G protein-coupled bile acid receptor 1 (Gpbar1/M-Bar) is a novel G protein-coupled receptor for bile acid. Tissue distribution… 
Highly Cited
2006
Highly Cited
2006
Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids.
The bile acid receptor farnesoid X receptor (FXR) is a key regulator of hepatic defense mechanisms against bile acids. A… 
Highly Cited
2006
Highly Cited
2006
The human Na+-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile…
Na+-taurocholate cotransporting polypeptide (NTCP) is the major bile acid uptake system in human hepatocytes. NTCP and the ileal… 
Highly Cited
2002
Highly Cited
2002
Human organic anion transporting polypeptide 8 promoter is transactivated by the farnesoid X receptor/bile acid receptor.
BACKGROUND & AIMS OATP8 (gene symbol: SLC21A8) is a multispecific uptake system for organic anions, xenobiotics, and peptides… 
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