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Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
The liver and intestine play crucial roles in maintaining bile acid homeostasis. Here, we demonstrate that fibroblast growth factor 15 (FGF15) signals from intestine to liver to repress the geneExpand
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Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c.
We explored the effects of bile acids on triglyceride (TG) homeostasis using a combination of molecular, cellular, and animal models. Cholic acid (CA) prevents hepatic TG accumulation, VLDLExpand
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Cholesterol gallstone disease
With a prevalence of 10-15% in adults in Europe and the USA, gallstones are the most common digestive disease needing admission to hospital in the West. The interplay between interprandial andExpand
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Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor.
Obstruction of bile flow results in bacterial proliferation and mucosal injury in the small intestine that can lead to the translocation of bacteria across the epithelial barrier and systemicExpand
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Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
Background & aims Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from dysregulation of the mucosal immune system and compromised intestinal epithelialExpand
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Deciphering the nuclear bile acid receptor FXR paradigm
Originally called retinoid X receptor interacting protein 14 (RIP14), the farnesoid X receptor (FXR) was renamed after the ability of its rat form to bind supra-physiological concentrations ofExpand
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REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis
The nuclear receptor REV-ERBα shapes the daily activity profile of Sterol Response Element Binding Protein (SREBP) and thereby participates in the circadian control of cholesterol and bile acidExpand
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Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
Cholesterol gallstone disease is characterized by several events, including cholesterol precipitation in bile, increased bile salt hydrophobicity and gallbladder inflammation. Here, we describe theExpand
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Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation ofExpand
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Nuclear bile acid receptor FXR protects against intestinal tumorigenesis.
Bile acids have been considered intestinal tumor promoters, and because they are natural ligands for the nuclear receptor FXR, we examined the role of FXR in intestinal tumorigenesis. Using gain- andExpand
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