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NPR1 protein, human

Known as: EC 4.6.1.2, Atrionatriuretic Peptide Receptor, Type A, Atrial Natriuretic Peptide Receptor Type A 
Atrial natriuretic peptide receptor 1 (1061 aa, ~119 kDa) is encoded by the human NPR1 gene. This protein plays a role in both guanylate cyclase… 
National Institutes of Health

Related topics

Related topics

15 relations
Blood CirculationEnzyme GeneGuanylate CyclaseIntegral Membrane Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Role of juxtamembrane and transmembrane domains in the mechanism of natriuretic peptide receptor A activation.
Natriuretic peptide receptor A (NPRA) is a noncovalent homodimeric receptor, composed of an extracellular domain (ECD) with a… 
2010
2010
Polymorphisms of Renin-Angiotensin System and Natriuretic Peptide Receptor A Genes in Patients of Greek Origin with a History of Myocardial Infarction
We assessed the association between (CA)n repeat polymorphism of angiotensinogen (AGT), 250 base pair (bp) insertion/deletion (I… 
Review
2009
Review
2009
Ligand-mediated endocytosis and intracellular sequestration of guanylyl cyclase/natriuretic peptide receptors: role of GDAY motif
The guanylyl cyclase/natriuretic peptide receptor-A (GC-A/NPRA), also referred to as GC-A, is a single polypeptide molecule… 
2008
2008
Role of Extracellular Domain Dimerization in Agonist-Induced Activation of Natriuretic Peptide Receptor A
Natriuretic peptide receptor (NPR) A is composed of an extracellular domain (ECD) with a ligand binding site, a single… 
2005
2005
Internalization and trafficking of guanylyl (guanylate) cyclase/natriuretic peptide receptor A is regulated by an acidic tyrosine-based cytoplasmic motif GDAY.
We have identified a GDAY motif in the C-terminal domain of guanylyl cyclase (guanylate cyclase)/NPRA (natriuretic peptide… 
2005
2005
Photolabeling study of the ligand binding domain of natriuretic peptide receptor A: development of a model.
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) are loop-shaped peptidic hormones that have multiple actions… 
2003
2003
Genistein Potentiates the ANP Effect on a K+-Conductance in HEK-293 Cells
HEK-293 cells are known to reflect many features of the late distal tubule. Furthermore, they have the ability to release… 
2001
2001
Molecular cloning of natriuretic peptide receptor A from bullfrog (Rana catesbeiana) brain and its functional expression.
2001
2001
Proteolytic activation of membrane-bound guanylate cyclase.
Highly Cited
1998
Highly Cited
1998
The guanylate cyclase–coupled natriuretic peptide receptor: A new target for prevention of cold ischemia–reperfusion damage of the rat liver
The aim of our studies was to investigate hormonal prevention of hepatic preservation damage by the atrial natriuretic peptide… 
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