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NPHS2 gene

Known as: NPHS2, PDCN, PODOCIN 
National Institutes of Health

Related topics

Related topics

4 relations
Idiopathic Nephrotic SyndromeLipoid nephrosisNEPHROTIC SYNDROME, STEROID-RESISTANT, AUTOSOMAL RECESSIVENPHS2 protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Endoplasmic reticulum stress in proteinuric kidney disease.
Endoplasmic reticulum (ER) stress refers to physiological or pathological states that result in accumulation of misfolded… 
Highly Cited
2005
Highly Cited
2005
Nephrin and podocin dissociate at the onset of proteinuria in experimental membranous nephropathy.
BACKGROUND The slit diaphragm plays a critical role in maintaining the barrier function of the glomerular capillary wall. The… 
Review
2004
Review
2004
Signaling at the slit diaphragm.
Diseases of the glomerular filter of the kidney are a leading cause of end-stage renal failure. Recent studies have emphasized… 
Highly Cited
2003
Highly Cited
2003
Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains.
Hereditary nephrotic syndrome is a heterogeneous disease, characterized by heavy proteinuria and renal failure. Mutations of… 
Highly Cited
2003
Highly Cited
2003
Expression of podocyte-associated molecules in acquired human kidney diseases.
Proteinuria is a poorly understood feature of many acquired renal diseases. Recent studies concerning congenital nephrotic… 
Review
2003
Review
2003
The role of podocytes in glomerular pathobiology
Podocytes are unique cells with a complex cellular organization. With respect to their cytoarchitecture, podocytes may be divided… 
Highly Cited
2003
Highly Cited
2003
Broadening the spectrum of diseases related to podocin mutations.
A total of 179 children with sporadic nephrotic syndrome were screened for podocin mutations: 120 with steroid resistance, and 59… 
Highly Cited
2002
Highly Cited
2002
NPHS2 mutations in late-onset focal segmental glomerulosclerosis: R229Q is a common disease-associated allele.
Mutations in NPHS2, encoding podocin, have been identified in childhood onset focal and segmental glomerulosclerosis (FSGS). The… 
Highly Cited
2002
Highly Cited
2002
Co-localization of nephrin, podocin, and the actin cytoskeleton: evidence for a role in podocyte foot process formation.
Highly Cited
2002
Highly Cited
2002
Determinants of Vascular Permeability in the Kidney Glomerulus*
The human kidneys filter 70 liters of blood plasma every day. The hallmark of almost all kidney diseases, whether acquired or… 
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