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NK 104

Known as: NK-104 
National Institutes of Health

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2 relations

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pitavastatinpitavastatin calcium

Papers overview

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Highly Cited
2001
Highly Cited
2001
Synthesis and biological evaluations of quinoline-based HMG-CoA reductase inhibitors.
2001
2001
Cholesterol-lowering Effect of NK-104, a 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitor, in Guinea Pig Model of Hyperlipidemia
Summary Although benefits of statins have been demonstrated even in normolipidemic patients at high risk, the main target of… 
2001
2001
Hypolipidemic Effect of NK-104 and Other 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors in Guinea Pigs
Summary Hypolipidemic effects of various HMG-CoAeductase inhibitors (statins) were examined in guinea pigs. After 2 week… 
2001
2001
Pitavastatin (NK-104), a new HMG-CoA reductase inhibitor.
Pitavastatin calcium (NK-104) is a new synthetic hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor (statin). Animal… 
2000
2000
Lipid-lowering and Antiatherosclerotic Effect of NK-104, a Potent 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Inhibitor, in Watanabe Heritable Hyperlipidemic Rabbits
Summary NK-104 ((+)-monocalcium bis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}, CAS… 
1999
1999
Identification of metabolites of NK-104, an HMG-CoA reductase inhibitor, in rat, rabbit and dog bile.
NK-104 is an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase with a very potent lipid-lowering effect… 
1999
1999
Simultaneous determination of NK-104 and its lactone in biological samples by column-switching high-performance liquid chromatography with ultraviolet detection.
1998
1998
NK-104, a newly developed HMG-CoA reductase inhibitor, suppresses neointimal thickening by inhibiting smooth muscle cell growth and fibronectin production in balloon-injured rabbit carotid artery.
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors have been reported to suppress smooth muscle cell growth and… 
Highly Cited
1997
Highly Cited
1997
Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Pharmacological properties of NK-104 ((+)-monocalcium bis¿(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl++ +]-3,5… 
1996
1996
Novel synthetic strategy for HMG-CoA reductase inhibitors
Abstract 
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