NFATC Transcription Factors
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Rationale: Both nuclear factors of activated T cells (NFAT) and nuclear factor-&kgr;B (NF&kgr;B) are Rel homology domain (RHD… Expand Nuclear factor of activated T cells (NFAT) proteins are Ca2+-regulated transcription factors that control gene expression in many… Expand Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We… Expand ABSTRACT Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor… Expand MCP-1 (monocyte chemotactic protein-1) is a CC chemokine that is induced by receptor activator of NFκB ligand (RANKL) in human… Expand Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of… Expand The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption… Expand NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have… Expand NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin… Expand As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of… Expand