NFATC Transcription Factors

Known as: Nuclear Factors of Activated T Cells, NFAT Proteins, Transcription Factor NF-AT 
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated… (More)
National Institutes of Health

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In BloodNFAT Transcription Factor 5Process of secretionagonists
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NF-ATNFAT Transcription Factor 2NFAT Transcription Factor 3NFAT Transcription Factor 4
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Papers overview

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Highly Cited
2011
Highly Cited
2011
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling.
RATIONALE Both nuclear factors of activated T cells (NFAT) and nuclear factor-κB (NFκB) are Rel homology domain (RHD)-containing… (More)
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Highly Cited
2011
Highly Cited
2011
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex.
Nuclear factor of activated T cells (NFAT) proteins are Ca(2+)-regulated transcription factors that control gene expression in… (More)
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Highly Cited
2010
Highly Cited
2010
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We… (More)
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2009
2009
RNAi screening: tips and techniques
799 Sonia Sharma and Anjana Rao are in the Department of Pathology, Harvard Medical School, Immune Disease Institute and the… (More)
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Highly Cited
2008
Highly Cited
2008
Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.
Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor in… (More)
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Highly Cited
2003
Highly Cited
2003
Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression.
Activation of transcription factors by receptor mediated signaling is an essential step for T lymphocyte effector function… (More)
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Highly Cited
2000
Highly Cited
2000
Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
The critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in mice lacking both NFATp and NFAT4 (DKO… (More)
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Review
2000
Review
2000
FK506, an immunosuppressant targeting calcineurin function.
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption… (More)
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2000
2000
African swine fever virus protein A238L interacts with the cellular phosphatase calcineurin via a binding domain similar to that of NFAT.
The African swine fever virus protein A238L inhibits activation of NFAT transcription factor by binding calcineurin and… (More)
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Highly Cited
1999
Highly Cited
1999
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have… (More)
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