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NFATC Transcription Factors

Known as: Nuclear Factors of Activated T Cells, NFAT Proteins, Transcription Factor NF-AT 
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated… Expand
National Institutes of Health

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15 relations
In BloodNFAT Transcription Factor 5Process of secretionagonists
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Narrower (6)

NF-ATNFAT Transcription Factor 1NFAT Transcription Factor 2NFAT Transcription Factor 3
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Papers overview

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Highly Cited
2015
Highly Cited
2015
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately result from a deficiency of functional… Expand
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Highly Cited
2012
Highly Cited
2012
Interaction Between NF&kgr;B and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling
Rationale: Both nuclear factors of activated T cells (NFAT) and nuclear factor-&kgr;B (NF&kgr;B) are Rel homology domain (RHD… Expand
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Highly Cited
2011
Highly Cited
2011
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
Nuclear factor of activated T cells (NFAT) proteins are Ca2+-regulated transcription factors that control gene expression in many… Expand
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Highly Cited
2010
Highly Cited
2010
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We… Expand
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Highly Cited
2008
Highly Cited
2008
Dual Roles for NFAT Transcription Factor Genes as Oncogenes and Tumor Suppressors
ABSTRACT Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor… Expand
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Highly Cited
2006
Highly Cited
2006
MCP-1-induced Human Osteoclast-like Cells Are Tartrate-resistant Acid Phosphatase, NFATc1, and Calcitonin Receptor-positive but Require Receptor Activator of NFκB Ligand for Bone Resorption*
MCP-1 (monocyte chemotactic protein-1) is a CC chemokine that is induced by receptor activator of NFκB ligand (RANKL) in human… Expand
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Review
2000
Review
2000
FK506, an immunosuppressant targeting calcineurin function.
  • F. Dumont
  • Current medicinal chemistry
  • 2000
    • Corpus ID: 25221758
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption… Expand
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Highly Cited
2000
Highly Cited
2000
Sequential involvement of NFAT and Egr transcription factors in FasL regulation.
The critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in mice lacking both NFATp and NFAT4 (DKO… Expand
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Highly Cited
1999
Highly Cited
1999
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have… Expand
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Highly Cited
1998
Highly Cited
1998
Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.
NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin… Expand
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