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NFATC Transcription Factors

Known as: Nuclear Factors of Activated T Cells, NFAT Proteins, Transcription Factor NF-AT 
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated… Expand
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Types 1 and 2 diabetes affect some 380 million people worldwide. Both ultimately result from a deficiency of functional… Expand
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Highly Cited
2012
Highly Cited
2012
Rationale: Both nuclear factors of activated T cells (NFAT) and nuclear factor-&kgr;B (NF&kgr;B) are Rel homology domain (RHD… Expand
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Highly Cited
2011
Highly Cited
2011
Nuclear factor of activated T cells (NFAT) proteins are Ca2+-regulated transcription factors that control gene expression in many… Expand
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Highly Cited
2010
Highly Cited
2010
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We… Expand
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Highly Cited
2008
Highly Cited
2008
ABSTRACT Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor… Expand
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Highly Cited
2006
Highly Cited
2006
MCP-1 (monocyte chemotactic protein-1) is a CC chemokine that is induced by receptor activator of NFκB ligand (RANKL) in human… Expand
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Review
2000
Review
2000
  • F. Dumont
  • Current medicinal chemistry
  • 2000
  • Corpus ID: 25221758
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption… Expand
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Highly Cited
2000
Highly Cited
2000
The critical function of NFAT proteins in maintaining lymphoid homeostasis was revealed in mice lacking both NFATp and NFAT4 (DKO… Expand
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Highly Cited
1999
Highly Cited
1999
NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have… Expand
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Highly Cited
1998
Highly Cited
1998
NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin… Expand
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