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NFATC Transcription Factors

Known as: Nuclear Factors of Activated T Cells, NFAT Proteins, Transcription Factor NF-AT 
A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated… Expand
National Institutes of Health

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15 relations
In BloodNFAT Transcription Factor 5Process of secretionagonists
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NF-ATNFAT Transcription Factor 1NFAT Transcription Factor 2NFAT Transcription Factor 3
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Interaction Between NF&kgr;B and NFAT Coordinates Cardiac Hypertrophy and Pathological Remodeling
Rationale: Both nuclear factors of activated T cells (NFAT) and nuclear factor-&kgr;B (NF&kgr;B) are Rel homology domain (RHD… Expand
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Highly Cited
2011
Highly Cited
2011
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complex
Nuclear factor of activated T cells (NFAT) proteins are Ca2+-regulated transcription factors that control gene expression in many… Expand
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Highly Cited
2010
Highly Cited
2010
Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T-cell activation at the immune synapse.
Engagement of T cells with antigen-presenting cells requires T-cell receptor (TCR) stimulation at the immune synapse. We… Expand
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Highly Cited
2008
Highly Cited
2008
Dual Roles for NFAT Transcription Factor Genes as Oncogenes and Tumor Suppressors
ABSTRACT Nuclear factor of activated T cells (NFAT) was first described as an activation and differentiation transcription factor… Expand
Highly Cited
2006
Highly Cited
2006
MCP-1-induced Human Osteoclast-like Cells Are Tartrate-resistant Acid Phosphatase, NFATc1, and Calcitonin Receptor-positive but Require Receptor Activator of NFκB Ligand for Bone Resorption*
MCP-1 (monocyte chemotactic protein-1) is a CC chemokine that is induced by receptor activator of NFκB ligand (RANKL) in human… Expand
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Review
2005
Review
2005
NFAT proteins: key regulators of T-cell development and function
  • F. Macian
  • Nature Reviews Immunology
  • 2005
    • Corpus ID: 2460785
Since the discovery of the first nuclear factor of activated T cells (NFAT) protein more than a decade ago, the NFAT family of… Expand
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Review
2000
Review
2000
FK506, an immunosuppressant targeting calcineurin function.
  • F. Dumont
  • Current medicinal chemistry
  • 2000
    • Corpus ID: 25221758
The macrolactam natural product, FK506 (Tacrolimus), acts as a powerful and clinically useful immnosuppressant through disruption… Expand
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Highly Cited
1999
Highly Cited
1999
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun.
NFAT transcription factors are related to NF-kappaB/Rel proteins and form cooperative complexes with Fos and Jun on DNA. We have… Expand
Highly Cited
1998
Highly Cited
1998
Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT.
NFAT transcription factors play a key role in the immune response. The activation of NFAT proteins is controlled by calcineurin… Expand
Review
1997
Review
1997
Transcription factors of the NFAT family: regulation and function.
As targets for the immunosuppressive drugs cyclosporin A and FK506, transcription factors of the NFAT (nuclear factor of… Expand
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