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Transcription factors of the NFAT family: regulation and function.
Recent data on the diversity of the NFAT family of transcription factors, the regulation of NFAT proteins within cells, and the cooperation ofNFAT proteins with other transcription factors to regulate the expression of inducible genes are discussed. Expand
Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1
It is shown here that TET1, a fusion partner of the MLL gene in acute myeloid leukemia, is a 2-oxoglutarate (2OG)- and Fe(II)-dependent enzyme that catalyzes conversion of 5mC to 5-hydroxymethylcytosine (hmC) in cultured cells and in vitro. Expand
A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function
It is proposed that Orai1 is an essential component or regulator of the CRAC channel complex, which contains four putative transmembrane segments and is based on a novel protein that was identified in SCID patients. Expand
Transcriptional regulation by calcium, calcineurin, and NFAT.
The NFAT family of transcription factors encompasses five proteins evolutionarily related to the Rel/NF B family, and it is clear that NFAT activates transcription of a large number of genes during an effective immune response. Expand
Global Epigenomic Reconfiguration During Mammalian Brain Development
The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits. Expand
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
Antigen stimulation of immune cells activates the transcription factor NFAT, a key regulator of T cell activation and anergy. NFAT forms cooperative complexes with the AP-1 family of transcriptionExpand
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Activation of the transcription factor nuclear factor kappa B (NF-κB) is controlled by sequential phosphorylation, ubiquitination, and degradation of its inhibitory subunit IκB. A large multiproteinExpand
Regulation of the Germinal Center Response by MicroRNA-155
It is shown that the evolutionarily conserved microRNA-155 has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell–dependent antibody response. Expand
Orai1 is an essential pore subunit of the CRAC channel
It is shown that Orai1 is a plasma membrane protein, and that CRAC channel function is sensitive to mutation of two conserved acidic residues in the transmembrane segments, which reduces Ca2+ influx, increases current carried by monovalent cations, and renders the channel permeable to Cs+. Expand
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells.
5hmC is an epigenetic modification associated with the pluripotent state, and Tet1 functions to regulate the lineage differentiation potential of ESCs. Expand