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NCSTN gene

Known as: KIAA0253, NCSTN, ANTERIOR PHARYNX DEFECTIVE 2, C. ELEGANS, HOMOLOG OF 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Structural basis of human γ-secretase assembly
Significance Unlike other single-component intramembrane proteases such as rhomboid and S2P, γ-secretase contains four components… 
2008
2008
Novel role of presenilins in maturation and transport of integrin beta 1.
Presenilins (PSs) play important roles in modulating the trafficking and maturation of several membrane proteins. However, the… 
2007
2007
p53-dependent Aph-1 and Pen-2 Anti-apoptotic Phenotype Requires the Integrity of the γ-Secretase Complex but Is Independent of Its Activity*
The presenilin-dependent γ-secretase activity, which is responsible for the generation of amyloid β-peptide, is a high molecular… 
Highly Cited
2006
Highly Cited
2006
Presenilin-Based Genetic Screens in Drosophila melanogaster Identify Novel Notch Pathway Modifiers
Presenilin is the enzymatic component of γ-secretase, a multisubunit intramembrane protease that processes several transmembrane… 
Highly Cited
2005
Highly Cited
2005
A Sequence within the First Transmembrane Domain of PEN-2 Is Critical for PEN-2-mediated Endoproteolysis of Presenilin 1*
Macromolecular complexes containing presenilins (PS), nicastrin (NCT), APH-1, and PEN-2 mediate the γ-secretase cleavage of the… 
Highly Cited
2005
Highly Cited
2005
Association of active gamma-secretase complex with lipid rafts.
Cholesterol has been implicated in the pathogenesis of Alzheimer's disease (AD). Although the underlying mechanisms are not yet… 
2005
2005
Length and overall sequence of the PEN‐2 C‐terminal domain determines its function in the stabilization of presenilin fragments
γ‐Secretase is an aspartyl protease complex that catalyzes the intramembrane cleavage of a subset of type I transmembrane… 
Review
2004
Review
2004
Uncovering gamma-secretase.
Accumulation of the amyloid beta-peptide (Abeta) in the brain is believed to initiate a series of neurotoxic events that causes… 
Review
2003
Review
2003
Identity and function of gamma-secretase.
gamma-Secretase catalyzes intramembrane proteolysis of various type I membrane proteins, including the amyloid-beta precursor… 
2002
2002
BACE1 interacts with nicastrin.
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