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NCSTN gene

Known as: KIAA0253, NCSTN, ANTERIOR PHARYNX DEFECTIVE 2, C. ELEGANS, HOMOLOG OF 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
A novel pathogenic NCSTN variant in a large Australian pedigree affected with hidradenitis suppurativa
2017
2017
Effects of the Gamma Secretase Inhibitors (GSI) Dapt (GSI-IX) and LSN424354 on Gene Expression and Shedding of Bcma from Multiple Myeloma and Chronic Lymphocytic Leukemia Tumor Cells
Introduction: Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients have high levels of solubilized (s) BCMA in… 
2014
2014
Nicastrin knockdown in keratinocytes induces expression profiles for decreased expression of cell cycle genes and increases gene expression related to type I interferon response
2013
2013
OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrin
The gamma (γ)-secretase holoenzyme is composed of four core proteins and cleaves APP to generate amyloid beta (Aβ), a key… 
2011
2011
Construction of Drug Screening Cell Model and Application to New Compounds Interfering Production and Accumulation of Beta-Amyloid by Inhibiting Gamma-Secretase
Alzheimer’s disease (AD) is a tenacious neurodegenerative dementia, characterized clinically by progressive loss of memory… 
2007
2007
Mechanisms of disease: Inhibiting γ-secretase activity
The -secretase complex cleaves amyloid precursor protein (APP; resulting in the release of amyloid-, a peptide that possibly… 
2005
2005
Alzheimer's disease: Targeting of Nicastrin to sub-cellular compartments and its influence on G-secretase complex activity
Review
2004
Review
2004
The Biochemical and Genetic Odyssey to the Function of a Nicastrin-Like Protein Christof
Á-Secretase is a high-molecular-weight protein complex required for the proteolytic processing of various transmembrane proteins… 
2003
2003
Quantum computing: Logic gateway
Two groups have created logic gates using pairs of trapped ions. As components of a quantum computer, these gates have the… 
2002
2002
Nicastrin significantly modifies risk for familial early-onset Alzheimer's disease in a Dutch population based sample