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NCOA3 wt Allele

Known as: ACTR, CAGH16, p/CIP 
Human NCOA3 wild-type allele in the vicinity of 20q12 is approximately 155 kb in length. This allele, which encodes nuclear receptor coactivator 3… 
National Institutes of Health

Related topics

Related topics

9 relations
20q12CARM1 Transcription Regulation PathwayChromatin Remodeling Complex and Coactivator PathwayHistone Acetylation

Broader (1)

NCOA3 gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Deregulated E2F and the AAA+ Coregulator ANCCA Drive Proto-Oncogene ACTR/AIB1 Overexpression in Breast Cancer
The proto-oncogene ACTR/AIB1, a coactivator for transcription factors such as the nuclear receptors and E2Fs, is frequently… 
Highly Cited
2006
Highly Cited
2006
The Activity and Stability of the Transcriptional Coactivator p/CIP/SRC-3 Are Regulated by CARM1-Dependent Methylation
ABSTRACT The transcriptional coactivator p/CIP(SRC-3/AIB1/ACTR/RAC3) binds liganded nuclear hormone receptors and facilitates… 
Highly Cited
2005
Highly Cited
2005
Generation and Characterization of Rac3 Knockout Mice
ABSTRACT Rac proteins are members of the Rho family of GTPases involved in the regulation of actin dynamics. The three highly… 
Highly Cited
2005
Highly Cited
2005
Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells
IntroductionThe metastatic progression of cancer is a direct result of the disregulation of numerous cellular signaling pathways… 
Highly Cited
2004
Highly Cited
2004
Expression of the nuclear coactivator AIB1 in normal and malignant breast tissue
The gene of the nuclear receptor coactivator AIB1 (amplified in breast cancer 1) is amplified in breast cancer cell lines as well… 
Highly Cited
2003
Highly Cited
2003
The MN1 oncoprotein synergizes with coactivators RAC3 and p300 in RAR-RXR-mediated transcription
The t(12;22) creates an MN1–TEL fusion gene leading to acute myeloid leukemia. The fusion partner TEL (ETV6) is a member of the… 
Highly Cited
2001
Highly Cited
2001
AIB1 enhances estrogen-dependent induction of cyclin D1 expression.
AIB1 was isolated as a gene amplified in breast cancer and encodes a protein that acts as a steroid receptor coactivator. The… 
Highly Cited
2001
Highly Cited
2001
An Isoform of the Coactivator AIB1 That Increases Hormone and Growth Factor Sensitivity Is Overexpressed in Breast Cancer*
The AIB1 (amplified in breast cancer 1) protein is a coactivator that potentiates the transcriptional activity of nuclear hormone… 
Highly Cited
2000
Highly Cited
2000
Regulation of somatic growth by the p160 coactivator p/CIP.
A family of p160 coactivators was initially identified based on ligand-dependent interactions with nuclear receptors and thought… 
Highly Cited
2000
Highly Cited
2000
Amplification and over‐expression of the AIB1 nuclear receptor co‐activator gene in primary gastric cancers
Our analysis of chromosomal aberrations in primary gastric cancers using comparative genomic hybridization has revealed novel… 
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