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NCK2 protein, human

Known as: NCKBeta, NCK adaptor protein 2, human, NCK Adaptor Protein 2 
Encoded by human NCK2 Gene, ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, associates with… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Adaptor Proteins, Signal TransducingOncogene Proteins
Adaptor Signaling Protein GeneCell ProliferationCytoskeletal ModelingNCK2 gene
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Papers overview

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2007
2007
Nckβ Adapter Controls Neuritogenesis by Maintaining the Cellular Paxillin Level
ABSTRACT The SH2/SH3 adapter Nck has an evolutionarily conserved role in neurons, linking the cell surface signals to actin… Expand
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Highly Cited
2006
Highly Cited
2006
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling.
Bidirectional signaling triggered by interacting ephrinB receptors (EphB) and ephrinB ligands is crucial for development and… Expand
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Highly Cited
2006
Highly Cited
2006
The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains*
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that modulate actin cytoskeleton dynamics by… Expand
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Highly Cited
2004
Highly Cited
2004
Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects.
The Rho family of small GTPases controls many biological processes, including cytoskeletal regulation, membrane trafficking, cell… Expand
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2003
2003
Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties.
  • Jianxing Song
  • The Journal of biological chemistry
  • 2003
    • Corpus ID: 29327719
Tyrosine phosphorylation of the 22-residue cytoplasmic region of ephrinB induces its binding to the SH2 domain of Grb4, thus… Expand
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2002
2002
Nck-2 interacts with focal adhesion kinase and modulates cell motility.
Nck-2 is a ubiquitously expressed adaptor protein comprising primarily three N-terminal SH3 domains and one C-terminal SH2 domain… Expand
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2001
2001
Identification and kinetic analysis of the interaction between Nck-2 and DOCK180.
Nck-2 is a newly identified adapter protein comprising three N-terminal SH3 domains and one C-terminal SH2 domain. We have… Expand
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2000
2000
Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb
ABSTRACT The SH3-SH3-SH3-SH2 adapter Nck represents a two-gene family that includes Nckα (Nck) and Nckβ (Grb4/Nck2), and it links… Expand
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Highly Cited
1998
Highly Cited
1998
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Many of the protein-protein interactions that are essential for eukaryotic intracellular signal transduction are mediated by… Expand
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1998
1998
Grb10 Identified as a Potential Regulator of Growth Hormone (GH) Signaling by Cloning of GH Receptor Target Proteins*
The cloning of receptor targets procedure, used so far to identify proteins associated with tyrosine kinase receptors was… Expand
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