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NCK2 protein, human

Known as: NCKBeta, NCK adaptor protein 2, human, NCK Adaptor Protein 2 
Encoded by human NCK2 Gene, ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, associates with… Expand
National Institutes of Health

Related topics

Related topics

10 relations

Broader (2)

Adaptor Proteins, Signal TransducingOncogene Proteins
Adaptor Signaling Protein GeneCell ProliferationCytoskeletal ModelingNCK2 gene
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Papers overview

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Highly Cited
2006
Highly Cited
2006
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB‐induced Src phosphorylation and signaling
Bidirectional signaling triggered by interacting ephrinB receptors (EphB) and ephrinB ligands is crucial for development and… Expand
Highly Cited
2006
Highly Cited
2006
The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains*
Nck proteins are essential Src homology (SH) 2 and SH3 domain-bearing adapters that modulate actin cytoskeleton dynamics by… Expand
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Highly Cited
2004
Highly Cited
2004
Wrch1 is a GTPase-deficient Cdc42-like protein with unusual binding characteristics and cellular effects.
The Rho family of small GTPases controls many biological processes, including cytoskeletal regulation, membrane trafficking, cell… Expand
2003
2003
Tyrosine phosphorylation of the well packed ephrinB cytoplasmic beta-hairpin for reverse signaling. Structural consequences and binding properties.
  • Jianxing Song
  • The Journal of biological chemistry
  • 2003
    • Corpus ID: 29327719
Tyrosine phosphorylation of the 22-residue cytoplasmic region of ephrinB induces its binding to the SH2 domain of Grb4, thus… Expand
2001
2001
Identification and kinetic analysis of the interaction between Nck‐2 and DOCK180
Nck‐2 is a newly identified adapter protein comprising three N‐terminal SH3 domains and one C‐terminal SH2 domain. We have… Expand
Highly Cited
2000
Highly Cited
2000
Nckβ Adapter Regulates Actin Polymerization in NIH 3T3 Fibroblasts in Response to Platelet-Derived Growth Factor bb
ABSTRACT The SH3-SH3-SH3-SH2 adapter Nck represents a two-gene family that includes Nckα (Nck) and Nckβ (Grb4/Nck2), and it links… Expand
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Highly Cited
1999
Highly Cited
1999
Identification of Grb4/Nckβ, a Src Homology 2 and 3 Domain-containing Adapter Protein Having Similar Binding and Biological Properties to Nck*
Adapter proteins made up of Src homology (SH) domains mediate multiple cellular signaling events initiated by receptor protein… Expand
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Highly Cited
1998
Highly Cited
1998
Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways.
Many of the protein-protein interactions that are essential for eukaryotic intracellular signal transduction are mediated by… Expand
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Highly Cited
1998
Highly Cited
1998
Grb10 Identified as a Potential Regulator of Growth Hormone (GH) Signaling by Cloning of GH Receptor Target Proteins*
  • Soraya Moutoussamy, Françoise Renaudie, Francisca Lago, Paul A. Kelly, Joelle Finidori
  • The Journal of Biological Chemistry
  • 1998
    • Corpus ID: 39690721
The cloning of receptor targets procedure, used so far to identify proteins associated with tyrosine kinase receptors was… Expand
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Highly Cited
1998
Highly Cited
1998
Identification of Nck Family Genes, Chromosomal Localization, Expression, and Signaling Specificity*
  • Min Chen, H. She, +5 authors Wei Li
  • The Journal of Biological Chemistry
  • 1998
    • Corpus ID: 25646097
Already a dozen molecules share binding to the Src homology (SH) 3 domains of human Nck, an SH3-SH3-SH3-SH2 adapter protein. We… Expand
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