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NB 598

Known as: Benzenemethanamine, 3-((3,3'-bithiophen)-5-ylmethoxy)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-ethyl-, (E)-, NB-598 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

BenzylaminesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Induction of CYP 3 A by 2 , 3-Oxidosqualene : Lanosterol Cyclase Inhibitors Is Mediated by an Endogenous Squalene Metabolite in Primary Cultured Rat Hepatocytes
The effects of inhibitors of 2,3-oxidosqualene:lanosterol cyclase (cyclase) on cytochrome P450 expression were investigated in… 
2003
2003
Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.M200316-JLR200
We recently demonstrated that squalene synthase (SQS) inhibitors reduce plasma triglyceride through an LDL receptor-independent… 
2000
2000
Photoaffinity labeling and site-directed mutagenesis of rat squalene epoxidase.
Squalene epoxidase (SE) (EC 1.14.99.7) is a flavin-requiring, non-cytochrome P-450 oxidase that catalyzes the conversion of… 
1997
1997
[Pharmacological control of biosynthesis pathway of mevalonate: effect on the proliferation of arterial smooth muscle cells].
The role of mevalonic acid (MVA) and its products (isoprenoids) in cell proliferation prompted us to investigate the effect of… 
Highly Cited
1996
Highly Cited
1996
Transcriptional Regulation of Squalene Epoxidase by Sterols and Inhibitors in HeLa Cells (*)
Regulation of squalene epoxidase (SE) gene expression was studied in comparison with those of 3-hydroxy-3-methylglutaryl-CoA (HMG… 
Highly Cited
1995
Highly Cited
1995
Molecular Cloning and Expression of Rat Squalene Epoxidase (*)
Squalene epoxidase (SE) (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of… 
1994
1994
Effects of NB-598, a squalene epoxidase inhibitor, on the secretion of apolipoprotein B
1992
1992
Effect of an inhibitor of squalene epoxidase, NB-598, on lipid metabolism in Hep G2 cells.
NB-598, a potent inhibitor of squalene epoxidase, inhibited cholesterol synthesis from [14C]acetate and induced intracellular… 
1991
1991
Hypolipidemic effects of NB-598 in dogs.
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