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Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes Published, JLR Papers in Press, October 16, 2002. DOI 10.1194/jlr.M200316-JLR200
TLDR
The results suggest that SQS inhibitors reduce triglyceride biosynthesis by suppressing fatty acid biosynthesis via an increase in intracellular farnesol and its derivatives. Expand
In Vitro and In Vivo Activities of E5700 and ER-119884, Two Novel Orally Active Squalene Synthase Inhibitors, against Trypanosoma cruzi
TLDR
In vivo studies indicated that E5700 was able to provide full protection against death and completely arrested the development of parasitemia when given at a concentration of 50 mg/kg of body weight/day for 30 days, while ER-119884 provided only partial protection. Expand
The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs.
TLDR
E5555 showed potent and selective inhibitory effects on guinea pig platelet aggregation induced by thrombin and TRAP and suggested that E5555 could be a therapeutic option for atherothrombotic disease. Expand
Squalene synthase inhibitors reduce plasma triglyceride through a low-density lipoprotein receptor-independent mechanism.
TLDR
It is demonstrated that squalene synthase inhibitors reduced plasma triglyceride through an LDL receptor-independent mechanism, which was distinct from that of the triglyceride-lowering action of atorvastatin or bezafibrate. Expand
Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-coa reductase inhibitors.
TLDR
Results demonstrate that ER-27856 had more potent hypocholesterolemic activity and less hepatotoxic effect than HMGRIs, and may contribute to the treatment of hypercholesterolesmic patients. Expand
Effect of the acyl-CoA:cholesterol acyltransferase inhibitor, E5324, on experimental atherosclerosis in rabbits.
TLDR
Results indicate that E5324 not only has hypocholesterolemic activity, but also may have a direct effect on the arterial wall in experimental atherosclerosis. Expand
Isolation of cDNA for a Xenopus sperm-specific basic nuclear protein (SP4) and evidence for expression of SP4 mRNA in primary spermatocytes.
TLDR
Northern hybridization of RNA extracted from primary spermatocytes and round sper matids on Days 0 and 6 with SP4 cDNA probe (pXSP531) showed that SP4 mRNA is present both inPrimary sperMatocytes and in round sPermatids as is protamine mRNA in the rainbow trout. Expand
Anti-atherosclerotic effect of E5324, an inhibitor of acyl-CoA:cholesterol acyltransferase, in Watanabe heritable hyperlipidemic rabbits.
TLDR
The results suggest that E5324 acts directly on the arterial wall through ACAT inhibition, and prevents the progression of atherosclerosis in WHHL rabbits. Expand
cDNA cloning and expression of Xenopus sperm‐specific basic nuclear protein 5 (SP5) gene
TLDR
Determination of the amino acid sequence of the N‐terminal regions of all the SPs(1–6) suggested that pXSP633 encodes SP5, whereas SPs3, 4, and 6 are derived from a second mRNA species, and SPs1 and 2 from a third mRNA species; it seems likely that the six SPs arederived from three different mRNA species. Expand
Synthesis of sperm-specific basic nuclear proteins (SPs) in cultured spermatids from Xenopus laevis.
TLDR
The accumulation and synthesis of sperm-specific basic nuclear proteins in Xenopus spermatids in vitro were studied by acid-urea-Triton polyacrylamide gel electrophoresis and fluorography and indicated that SP2 was processed from a precursor protein which is probably SP1. Expand
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