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N-monodemethyldiltiazem

Known as: N-demethyldiltiazem, N-desmethyldiltiazem 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Diltiazem
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
Predictive models of complex drug-drug interactions between multiple inhibitors and their metabolites have not been evaluated… 
1996
1996
Multicenter studies on the pharmacokinetic profile of sustained-release oral diltiazem (300 mg) after once a day repeated administration: influence of age.
The influence of age on the pharmacokinetics of the oral sustained release diltiazem Mono-Tildiem LP 300 mg was investigated in… 
1995
1995
The Site of Absorption in the Small Intestine Determines Diltiazem Bioavailability in the Rabbit
AbstractPurpose. Since the ability of the small intestine to biotransform a drug may decrease in distal segments of the intestine… 
1995
1995
Metabolism of Diltiazem in Hepatic and Extrahepatic Tissues of Rabbits: InVitro Studies
Diltiazem (DTZ) is a calcium channel blocker widely used in the treatment of angina and hypertension. DTZ undergoes extensive… 
1994
1994
Effect of cardiopulmonary bypass on plasma concentrations of diltiazem and its two active metabolites
Abstract— Diltiazem is often used to prevent myocardial ischaemia during the perioperative period of coronary artery bypass… 
1993
1993
[Plasma concentrations of diltiazem and its metabolites in coronary surgery: relation with preoperative treatment].
Preoperative oral administration of calcium channel blocking agents has been found ineffective to prevent perioperative… 
1992
1992
Pharmacokinetics of diltiazem and a new analogue, LR-A/113, in the conscious rat
SummaryPharmacokinetics and metabolism of diltiazem and a new analogue, LR-A/113, have been studied in the rat Conscious rats… 
1992
1992
Simple and sensitive high-performance liquid chromatographic method for the determination of diltiazem and six of its metabolites in human plasma.
1990
1990
Metabolite inhibition of parent drug biotransformation. Studies of diltiazem.
Previously, we have demonstrated in vivo, in humans, nonlinear diltiazem disposition with an elimination half-life 50-100… 
1987
1987
High-performance liquid chromatographic determination of diltiazem and its major metabolites, N-monodemethyldiltiazem and desacetyldiltiazem, in plasma.
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