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N-caproylsphingosine

Known as: C(6)-ceramide, C6-ceramide, N-Hexanoylsphingosine 
National Institutes of Health

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Broader (1)

Ceramides

Papers overview

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Highly Cited
2006
Highly Cited
2006
Suicidal death of erythrocytes in recurrent hemolytic uremic syndrome
Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia with fragmented erythrocytes, thrombocytopenia, and acute… 
Highly Cited
2002
Highly Cited
2002
PKC-dependent Activation of Sphingosine Kinase 1 and Translocation to the Plasma Membrane
Sphingosine-1-phosphate (S1P) is a highly bioactive sphingolipid involved in diverse biological processes leading to changes in… 
Highly Cited
2002
Highly Cited
2002
Biochemical Mechanisms of the Generation of Endogenous Long Chain Ceramide in Response to Exogenous Short Chain Ceramide in the A549 Human Lung Adenocarcinoma Cell Line
Treatment of A549 cells with C6-ceramide resulted in a significant increase in the endogenous long chain ceramide levels, which… 
Highly Cited
2000
Highly Cited
2000
Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells
Etoposide (VP-16) a topoisomerase II inhibitor induces apoptosis of tumor cells. The present study was designed to elucidate the… 
Highly Cited
1999
Highly Cited
1999
Ceramide Induces Cytochrome c Release from Isolated Mitochondria
In the present study we show thatN-acetylsphingosine (C2-ceramide),N-hexanoylsphingosine (C6-ceramide), and, to a much lesser… 
Highly Cited
1998
Highly Cited
1998
Ceramide Regulates the Transcription of Cyclooxygenase-2
The ceramide signaling pathway is activated by the sphingomyelinase (SMase)-mediated hydrolysis of cell membrane sphingomyelin to… 
Highly Cited
1997
Highly Cited
1997
Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases.
The n-type K+ channel (n-K+, Kv1.3) in lymphocytes has been recently implicated in the regulation of Fas-induced programmed cell… 
Highly Cited
1996
Highly Cited
1996
Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.
We have previously demonstrated that chronic exposure of 3T3-L1 adipocytes to tumour necrosis factor-alpha (TNF) resulted in a… 
Highly Cited
1993
Highly Cited
1993
Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells.
Highly Cited
1992
Highly Cited
1992
Ceramide stimulates a cytosolic protein phosphatase.
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