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N-Myc Downstream Regulated Protein 1

Known as: Reducing Agents and Tunicamycin-Responsive Protein, Tunicamycin-Responsive Protein, Differentiation-Related Gene 1 Protein 
Protein NDRG1 (394 aa, ~43 kDa) is encoded by the human NDRG1 gene. This protein may play a role in the cellular response to chemical stress.
National Institutes of Health

Related topics

Related topics

7 relations

Broader (1)

Cell Cycle Proteins
Cell Differentiation processCell ProliferationCellular Stress ResponseGenes, Regulator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
The Metastasis Suppressor, N-MYC Downstream-regulated Gene-1 (NDRG1), Down-regulates the ErbB Family of Receptors to Inhibit Downstream Oncogenic Signaling Pathways*
N-MYC downstream-regulated gene-1 (NDRG1) is a potent growth and metastasis suppressor that acts through its inhibitory effects… 
Review
2012
Review
2012
Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.
Highly Cited
2011
Highly Cited
2011
The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.
The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), has been shown to markedly reduce metastasis of numerous… 
Highly Cited
2011
Highly Cited
2011
KAI1 Gene Is Engaged in NDRG1 Gene-mediated Metastasis Suppression through the ATF3-NFκB Complex in Human Prostate Cancer*
NDRG1 and KAI1 belong to metastasis suppressor genes, which impede the dissemination of tumor cells from primary tumors to… 
Highly Cited
2010
Highly Cited
2010
Ablation of the Kinase NDR1 Predisposes Mice to the Development of T Cell Lymphoma
The kinase NDR1 functions as a haploinsufficient tumor suppressor by ensuring proper apoptotic responses. Lymphoma from… 
Highly Cited
2007
Highly Cited
2007
The N-Myc Down Regulated Gene1 (NDRG1) Is a Rab4a Effector Involved in Vesicular Recycling of E-Cadherin
Cell to cell adhesion is mediated by adhesion molecules present on the cell surface. Downregulation of molecules that form the… 
Highly Cited
2006
Highly Cited
2006
N-Myc Down-regulated Gene 1 Modulates the Response of Term Human Trophoblasts to Hypoxic Injury*
The placenta is susceptible to diverse insults during human pregnancy. The expression of the protein N-myc down-regulated gene 1… 
Highly Cited
2005
Highly Cited
2005
Identification of differentially expressed genes in oral squamous cell carcinoma (OSCC): Overexpression of NPM, CDK1 and NDRG1 and underexpression of CHES1
To identify cellular genes that could potentially serve as predictive molecular markers for human oral cancer, we employed… 
Highly Cited
2004
Highly Cited
2004
Human Mob Proteins Regulate the NDR1 and NDR2 Serine-Threonine Kinases*
Human NDR1 (nuclear Dbf2-related) is a widely expressed nuclear serine-threonine kinase that has been implicated in cell… 
Highly Cited
1998
Highly Cited
1998
Cap43, a novel gene specifically induced by Ni2+ compounds.
To better understand the molecular mechanism(s) involved in the essentiality, toxicity, and/or carcinogenicity of nickel… 
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