N-Myc Downstream Regulated Protein 1

Known as: Reducing Agents and Tunicamycin-Responsive Protein, Tunicamycin-Responsive Protein, Differentiation-Related Gene 1 Protein 
Protein NDRG1 (394 aa, ~43 kDa) is encoded by the human NDRG1 gene. This protein may play a role in the cellular response to chemical stress.
National Institutes of Health

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Broader (1)

Cell Cycle Proteins
Cell Differentiation processCell ProliferationCellular Stress ResponseGenes, Regulator
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Papers overview

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2014
2014
The metastasis suppressor, N-myc downstream-regulated gene 1 (NDRG1), inhibits stress-induced autophagy in cancer cells.
N-myc downstream regulated gene 1 (NDRG1) is a potent metastasis suppressor with an undefined role in the stress response… (More)
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2014
2014
Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma.
Hepatocellular carcinoma (HCC) is the fifth most lethal malignancy worldwide with no curative therapies. To discover potentially… (More)
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Highly Cited
2012
Highly Cited
2012
The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1).
The epithelial-mesenchymal transition (EMT) is a key step for cancer cell migration, invasion, and metastasis. Transforming… (More)
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2011
2011
The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), upregulates p21 via p53-independent mechanisms.
The metastasis suppressor, N-myc downstream regulated gene-1 (NDRG1), has been shown to markedly reduce metastasis of numerous… (More)
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2011
2011
Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression
N-myc downstream-regulated gene-1 (NDRG1) has been identified as a protein involved in the differentiation of epithelial cells… (More)
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2011
2011
Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron.
N-Myc downstream-regulated gene 1 (NDRG1) is a ubiquitous cellular protein that is up-regulated under a multitude of stress and… (More)
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2010
2010
Transcriptional silencing of N-Myc downstream-regulated gene 1 (NDRG1) in metastatic colon cancer cell line SW620
N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in… (More)
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2010
2010
N-myc Downstream-regulated Gene 1 (NDRG1) a Differentiation Marker of Human Breast Cancer
N-myc downstream-regulated gene 1 (NDRG1), also called differentiation-related gene-1 (Drg1) and Cap43, is expressed in various… (More)
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2010
2010
A Deletion in the N-Myc Downstream Regulated Gene 1 (NDRG1) Gene in Greyhounds with Polyneuropathy
The polyneuropathy of juvenile Greyhound show dogs shows clinical similarities to the genetically heterogeneous Charcot-Marie… (More)
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Highly Cited
2008
Highly Cited
2008
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1).
SGK1 (serum- and glucocorticoid-induced protein kinase 1) is a member of the AGC (protein kinase A/protein kinase G/protein… (More)
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