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Interferon‐induced binding of nuclear factors to promoter elements of the 2‐5A synthetase gene.
Fragments of the 5′‐flanking sequence of a human 2‐5A synthetase gene were assayed for their ability to respond to interferon‐alpha (IFN), demonstrating the presence of three IFN‐modulated, DNA‐factor band shifts using nuclear extracts prepared from human and monkey cells. Expand
Combinations of anti-transferrin receptor monoclonal antibodies inhibit human tumor cell growth in vitro and in vivo: evidence for synergistic antiproliferative effects.
It is concluded that combinations of two or more anti-Tf receptor MAbs can interact synergistically to inhibit cell growth in vitro and tumor growth in vivo. Expand
The murine 2-5A synthetase locus: three distinct transcripts from two linked genes.
All transcripts present in IFN-treated mouse cells which are recognized by the available murine 2-5A synthetase cDNA probes map to an approximately 40 kb region of the mouse genome containing two 2- 5A Synthetase genes. Expand
Specific binding of the ETS-domain protein to the interferon-stimulated response element.
Coexpression of Ets-1 represses ISRE-dependent reporter activity, suggesting that one or more members of the Ets protein family may negatively regulate transcriptional activity mediated by the 2-5A synthetase ISRE. Expand
Expression of interferon-induced genes in different tissues of mice
In vivo responses to interferon (IFN) in mice were determined by measuring the steady-state levels of induced mRNAs following injection of IFN and poly(I)-poly(C). With cDNA probes for mouse 2'-5'Expand
Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor.
In murine BALB/c 3T3 cell cultures, either beta interferon or platelet-derived growth factor (PDGF) enhanced expression of the 2',5'-oligoadenylate synthetase mRNA and protein, which suggested that induction by PDGF requires interferons. Expand
Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation.
Examination of expression of E2A was evaluated using immunohistochemistry on histological sections of primary human tissues and results suggest that regulation of E 2A abundance complements protein-protein interactions in modulating E1A function. Expand
Formation of tubuloreticular inclusions in human lymphoma cells compared to the induction of 2'-5'-oligoadenylate synthetase by leucocyte interferon in dose-effect and kinetic studies.
TRI morphogenesis appeared to be independent of several other known biological actions of interferons and manifested later than the induction of 2'-5'-oligoadenylate synthetase activity which has been correlated with establishment of the antiviral state and occurred in cell lines, including DaudiKIFNR, which resist the growth-inhibitory effects of leukocyte interferon. Expand
Functional differences in the promoters of the interferon-inducible (2'-5')A oligoadenylate synthetase and 6-16 genes in interferon-resistant Daudi cells.
A clone of interferon-alpha-resistant (IFNr) Daudi cells retained much greater transcriptional inducibility of the (2'-5') oligoadenylate synthetase than the 6-16 gene despite the fact that theExpand
Expression of intracellular interferon constitutively activates ISGF3 and confers resistance to EMC viral infection.
It is shown that mouse L cells expressing nonsecreted type I human IFN are less susceptible to encephalomyocarditis (EMC) virus infection and have increased levels of 2-5A synthetase, suggesting that the internalization of IFN-alpha may play a role in the antiviral properties associated with IFN. Expand