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N,N-diethylazasqualene

Known as: DAZS, daz 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Aza CompoundsSqualene
analogs & derivatives

Papers overview

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Highly Cited
2010
Highly Cited
2010
Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm†
BACKGROUND Successful gametogenesis requires the establishment of an appropriate epigenetic state in developing germ cells… Expand
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Highly Cited
2003
Highly Cited
2003
Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-Like proteins
Early in development, a part of the embryo is set aside to become the germ cell lineage that will ultimately differentiate to… Expand
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Highly Cited
2002
Highly Cited
2002
Strong male-driven evolution of DNA sequences in humans and apes
Studies of human genetic diseases have suggested a higher mutation rate in males than in females and the male-to-female ratio… Expand
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Highly Cited
2000
Highly Cited
2000
Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome.
The DAZ genes are candidate fertility factors that lie within the human Y chromosome's AZFc region, whose deletion is a common… Expand
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Highly Cited
1999
Highly Cited
1999
Human male infertility and Y chromosome deletions: role of the AZF-candidate genes DAZ, RBM and DFFRY.
Microdeletions in Yq11 overlapping three distinct 'azoospermia factors' (AZFa-c) represent the aetiological factor of 10-15% of… Expand
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Highly Cited
1998
Highly Cited
1998
A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule.
We have identified a localized RNA component of Xenopus germ plasm. This RNA, Xdazl (Xenopus DAZ-like), encodes a protein… Expand
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Highly Cited
1997
Highly Cited
1997
The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis
RBM and DAZ/SPGY are two families of genes located on the Y chromosome that encode proteins containing RNA-binding motifs, and… Expand
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Highly Cited
1996
Highly Cited
1996
The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned
It is widely believed that most or all Y–chromosomal genes were once shared with the X chromosome. The DAZ gene is a candidate… Expand
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Highly Cited
1996
Highly Cited
1996
Substantial prevalence of microdeletions of the Y-chromosome in infertile men with idiopathic azoospermia and oligozoospermia detected using a sequence-tagged site-based mapping strategy.
Genes on the long arm of Y (Yq), particularly within interval 6, are believed to play a critical role in human spermatogenesis… Expand
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Highly Cited
1995
Highly Cited
1995
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA–binding protein gene
We have detected deletions of portions of the Y chromosome long arm in 12 of 89 men with azoospermia (no sperm in semen). No Y… Expand
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