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Human Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11.
In a large collaborative screening project, 370 men with idiopathic azoospermia or severe oligozoospermia were analysed for deletions of 76 DNA loci in Yq11. In 12 individuals, we observed de novoExpand
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The follicle-stimulating hormone receptor: biochemistry, molecular biology, physiology, and pathophysiology.
I. Introduction II. Biochemical Properties of the FSH Receptor: A Historical Prelude III. Molecular Structure of the FSH Receptor A. Cloning of the FSH receptor B. Predicted primary structure of theExpand
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Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure
Hypergonadotropic ovarian dysgenesis (ODG) with normal karyotype is a heterogeneous condition that in some cases displays Mendelian recessive inheritance. By systematically searching for linkage inExpand
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Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations.
The new ISA, ISSAM, EAU, EAA and ASA recommendations on the investigation, treatment and monitoring of late-onset hypogonadism in males provide updated evidence-based information for clinicians whoExpand
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Ovarian response to follicle-stimulating hormone (FSH) stimulation depends on the FSH receptor genotype.
Because the ovarian response to FSH stimulation in assisted reproduction is variable, ranging from hyporesponse to hyperresponse, with the possible complication of ovarian hyperstimulation, it wouldExpand
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Investigation, treatment, and monitoring of late-onset hypogonadism in males: ISA, ISSAM, EAU, EAA, and ASA recommendations.
Christina Wang *, Eberhard Nieschlag , Ronald Swerdloff , Hermann M. Behre , Wayne J. Hellstrom , Louis J. Gooren , Jean M. Kaufman , Jean-Jacques Legros , Bruno Lunenfeld , Alvaro Morales , John E.Expand
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Partial deletions in the AZFc region of the Y chromosome occur in men with impaired as well as normal spermatogenesis.
BACKGROUND Partial deletions of the AZFc region of the Y chromosome were reported to be a significant risk factor for oligo-/azoospermia. In this study, we assessed the occurrence and frequency ofExpand
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Andrology : male reproductive health and dysfunction
Scope and Goals * Biology of Reproduction,- Physiologym * Sperm Maturation and Fertilization * Classification of Andrological Disorders * Diagnosis of Male Infertility and Hypogonadism * Diseases ofExpand
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Germ cell transplantation into X-irradiated monkey testes.
BACKGROUND An intense debate is ongoing regarding options for fertility protection in oncological patients. Germ cell transplantation has been applied to restore mouse spermatogenesis. Here, anExpand
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Distinct spectrum of CFTR gene mutations in congenital absence of vas deferens
Abstract Congenital absence of the vas deferens (CAVD) is a frequent cause for obstructive azoospermia and accounts for 1%–2% of male infertility. A high incidence of mutations of the cystic fibrosisExpand
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