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Adult male mice were treated with one or two different doses of each of 18 different cytotoxic agents. They were sampled at… Expand Busulfan is a bifunctional alkylating agent that appears to be cytotoxic to slowly proliferating or non-proliferating stem cell… Expand The comparative metabolism of the enantiomers of cyclo phosphamide and of the racemate has been studied in humans. Four patients… Expand The sperm of (C57BL X C3H)F1 mice were examined 1, 4, and 10 weeks after a subacute treatment with one of 25 chemicals at two or… Expand Development of side-effects after long-term treatment with busulfan is described in a 61-year-old woman with chronic myelogenous… Expand The selectivity of action of alkylating agents and drug resistance. II. A comparison of the effects of alkylating drugs on growth… Expand A female infant, born of a mother with leukemia who received 6-mercaptopurine and x-ray therapy early in the pregnancy and… Expand The chief role of 1,4-dimethanesulfonyloxybutane (busulfan, Myleran) is in the treatment of chronic granulocytic leukemia. The… Expand ELSON (1955) has described the effects on the peripheral blood counts of the rat of a typical ‘nitrogen mustard’, chloranibucil… Expand In the hope of finding a less toxic analogue of nitrogen mustard, Haddow replaced the methyl groups in the nitrogen mustard… Expand