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Myeloid Leukemia

Known as: LEUKEMIA, GRANULOCYTIC, MALIGNANT, Myelocytic Leukemias, Unspecified myeloid leukemia 
A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are… Expand
National Institutes of Health

Related topics

Related topics

48 relations
ABL2 geneABL2 wt AlleleANXA8 geneAcute Promyelocytic Leukemia
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Narrower (8)

Acute myelomonocytic leukemiaEosinophilic leukemiaGranulocytic SarcomaLeukemia, Myelocytic, Acute
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Broader (3)

Neoplasm, uncertain whether benign or malignantNeoplasmsleukemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Targeting FLT3 mutations in AML: review of current knowledge and evidence
Genomic investigations of acute myeloid leukemia (AML) have demonstrated that several genes are recurrently mutated, leading to… Expand
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Review
2019
Review
2019
Emerging treatment paradigms with FLT3 inhibitors in acute myeloid leukemia
Mutations in the fms-like tyrosine kinase 3 (FLT3) gene are detected in approximately one-third of patients with newly diagnosed… Expand
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Review
2019
Review
2019
Epigenetic therapy combinations in acute myeloid leukemia: what are the options?
Epigenetics refers to the regulation of gene expression mainly by changes in DNA methylation and modifications of histone… Expand
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Review
2019
Review
2019
New Targeted Agents in Acute Myeloid Leukemia: New Hope on the Rise
The therapeutic approach for acute myeloid leukemia (AML) remains challenging, since over the last four decades a stagnation in… Expand
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Review
2019
Review
2019
Genetics of MDS.
Our knowledge about the genetics of myelodysplastic syndromes (MDS) and related myeloid disorders has been dramatically improved… Expand
Review
2019
Review
2019
Selective targeting of antiapoptotic BCL‐2 proteins in cancer
Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis. Extensively established key… Expand
Review
2019
Review
2019
Targeting Mcl-1 and other Bcl-2 family member proteins in cancer therapy.
Regulation of both the extrinsic and the mitochondria-dependent intrinsic apoptotic pathways plays a key role in the development… Expand
Review
2018
Review
2018
Nrf2 at the heart of oxidative stress and cardiac protection.
The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the expression of antioxidant and detoxification… Expand
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Review
2018
Review
2018
Mechanisms of receptor tyrosine kinase activation in cancer
Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes including growth, motility… Expand
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Review
2018
Review
2018
The bone-marrow niche in MDS and MGUS: implications for AML and MM
Several haematological malignancies, including multiple myeloma (MM) and acute myeloid leukaemia (AML), have well-defined… Expand
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