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Multiple Transition Abnormalities

Known as: Multiple Transition Mutations, Transition Mutations 
Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base… Expand
National Institutes of Health

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Related topics

2 relations
CYP2D6*17 AlleleTransition Mutation

Papers overview

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Highly Cited
2017
Highly Cited
2017
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
The spontaneous deamination of cytosine is a major source of transitions from C•G to T•A base pairs, which account for half of… Expand
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Review
2007
Review
2007
Molecular mechanisms of antibody somatic hypermutation.
Functional antibody genes are assembled by V-D-J joining and then diversified by somatic hypermutation. This hypermutation… Expand
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Review
2005
Review
2005
Mutations induced by ultraviolet light.
The different ultraviolet (UV) wavelength components, UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm), have distinct… Expand
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Highly Cited
2004
Highly Cited
2004
Activation-induced Cytidine Deaminase Deaminates 5-Methylcytosine in DNA and Is Expressed in Pluripotent Tissues
DNA deaminases of the Aid/Apobec family convert cytosine into uracil and play key roles in acquired and innate immunity. The… Expand
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Highly Cited
2004
Highly Cited
2004
APOBEC3F Properties and Hypermutation Preferences Indicate Activity against HIV-1 In Vivo
APOBEC3G (CEM15 ) deaminates cytosine to uracil in nascent retroviral cDNA. The potency of this cellular defense is evidenced by… Expand
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Review
1997
Review
1997
Cytosine methylation and the ecology of intragenomic parasites.
Most of the 5-methylcytosine in mammalian DNA resides in transposons, which are specialized intragenomic parasites that represent… Expand
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Highly Cited
1996
Highly Cited
1996
An approach to random mutagenesis of DNA using mixtures of triphosphate derivatives of nucleoside analogues.
We describe a new method for random mutagenesis of DNA based on the use of a mixture of triphosphates of nucleoside analogues… Expand
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Highly Cited
1995
Highly Cited
1995
Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.
The level of genetic variation of human immunodeficiency virus type 1 (HIV-1), a member of the lentivirus genus of the… Expand
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Highly Cited
1991
Highly Cited
1991
Spectra of spontaneous and mutagen-induced mutations in the lacI gene in transgenic mice.
Transgenic mice with a lambda shuttle vector containing a lacI target gene were generated for use as a short-term, in vivo… Expand
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Highly Cited
1978
Highly Cited
1978
Mutagenesis at a specific position in a DNA sequence.
Predefined changes in a known DNA sequence were introduced by a general method. Oligodeoxyribonucleotides complementary to… Expand
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