Multiple Transition Abnormalities

Known as: Multiple Transition Mutations, Transition Mutations 
Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base… (More)
National Institutes of Health

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CYP2D6*17 AlleleTransition Mutation

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Highly Cited
2017
Highly Cited
2017
Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage
The spontaneous deamination of cytosine is a major source of transitions from C•G to T•A base pairs, which account for half of… (More)
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Highly Cited
2012
Highly Cited
2012
Differential relationship of DNA replication timing to different forms of human mutation and variation.
Human genetic variation is distributed nonrandomly across the genome, though the principles governing its distribution are only… (More)
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Review
2005
Review
2005
Mutations induced by ultraviolet light.
The different ultraviolet (UV) wavelength components, UVA (320-400 nm), UVB (280-320 nm), and UVC (200-280 nm), have distinct… (More)
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Highly Cited
2004
Highly Cited
2004
Activation-induced cytidine deaminase deaminates 5-methylcytosine in DNA and is expressed in pluripotent tissues: implications for epigenetic reprogramming.
DNA deaminases of the Aid/Apobec family convert cytosine into uracil and play key roles in acquired and innate immunity. The… (More)
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Highly Cited
2004
Highly Cited
2004
APOBEC3F Properties and Hypermutation Preferences Indicate Activity against HIV-1 In Vivo
APOBEC3G (CEM15 ) deaminates cytosine to uracil in nascent retroviral cDNA. The potency of this cellular defense is evidenced by… (More)
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Highly Cited
2000
Highly Cited
2000
Relationship of Ki-ras mutations in colon cancers to tumor location, stage, and survival: a population-based study.
Some previous studies have demonstrated significant results between Ki-ras mutations and tumor stage, survival, and/or other… (More)
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Review
1997
Review
1997
Cytosine methylation and the ecology of intragenomic parasites.
Most of the 5-methylcytosine in mammalian DNA resides in transposons, which are specialized intragenomic parasites that represent… (More)
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Highly Cited
1996
Highly Cited
1996
Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori.
Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients… (More)
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Highly Cited
1982
Highly Cited
1982
Patterns of nucleotide substitution in pseudogenes and functional genes
The pattern of point mutations is inferred from nucleotide substitutions in pseudogenes. The pattern obtained suggests that… (More)
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Highly Cited
1978
Highly Cited
1978
Mutagenesis at a specific position in a DNA sequence.
Predefined changes in a known DNA sequence were introduced by a general method. Oligodeoxyribonucleotides complementary to… (More)
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