Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

Mitotane

Known as: 2, 4'-Dichlorodiphenyldichloroethane, 1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane, Mitotanum 
A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties. Following its metabolism in… Expand
National Institutes of Health

Related topics

Related topics

17 relations

Broader (1)

Antineoplastic Agents, Hormonal

Narrower (3)

ChloditanChlodithanemitometh
Cushing SyndromeDrug AllergyIn BloodMitotane:MCnc:Pt:Ser/Plas:Qn
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Role of Mitotane in Adrenocortical Carcinoma – Review and State of the art
Abstract Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine tumour deriving from the adrenal cortex. A correct… Expand
Review
2018
Review
2018
European Society of Endocrinology Clinical Practice Guidelines on the Management of Adrenocortical Carcinoma in Adults, in collaboration with the European Network for the Study of Adrenal Tumors.
Adrenocortical carcinoma (ACC) is a rare and in most cases steroid hormone producing tumor with variable prognosis. The purpose… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Highly Cited
2007
Highly Cited
2007
Adjuvant mitotane treatment for adrenocortical carcinoma.
BACKGROUND Adrenocortical carcinoma is a rare neoplasm characterized by a high risk of recurrence after radical resection… Expand
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Highly Cited
2007
Highly Cited
2007
Determination of pesticide residues in foods by acetonitrile extraction and partitioning with magnesium sulfate: collaborative study.
  • S. Lehotay
  • Journal of AOAC International
  • 2007
    • Corpus ID: 27125868
A collaborative study was conducted to determine multiple pesticide residues in fruits and vegetables using a quick, simple… Expand
Highly Cited
2004
Highly Cited
2004
Detrimental Ventricular Remodeling in Patients With Congenital Complete Heart Block and Chronic Right Ventricular Apical Pacing
Background—Although dual-chamber pacing improves cardiac function in patients with complete congenital atrioventricular block… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • table 3
Highly Cited
1998
Highly Cited
1998
Several environmental oestrogens are also anti-androgens.
There is presently considerable interest in endocrine disruption which is a new area of endocrinology concerned with chemicals… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
1998
Highly Cited
1998
Acute hemodynamic effects of biventricular DDD pacing in patients with end-stage heart failure.
OBJECTIVES The aim of this study was to assess the potential acute benefit of multisite cardiac pacing with optimized… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Highly Cited
1994
Highly Cited
1994
Optimal treatment of adrenocortical carcinoma with mitotane: results in a consecutive series of 96 patients.
Mitotane is considered to be the drug of choice for patients with inoperable, recurrent and metastatic adrenocortical carcinoma… Expand
  • table I
  • figure 1
  • figure 2
  • figure 3
  • table II
Highly Cited
1992
Highly Cited
1992
Effects of dual-chamber pacing with short atrioventricular delay in dilated cardiomyopathy
Mitral or tricuspid regurgitation of long duration may so shorten the ventricular filling time in dilated cardiomyopathy that… Expand
Highly Cited
1990
Highly Cited
1990
Clinical features of adrenocortical carcinoma, prognostic factors, and the effect of mitotane therapy.
Adrenocortical carcinoma is a rare tumor, and only limited information is available about its natural history and the effects of… Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE