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Chloditan

Known as: Khloditan 
National Institutes of Health

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1 relation

Broader (1)

Mitotane

Papers overview

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2012
2012
Adrenocorticolytic activity of o,p′-DDD (chloditan) solution in in vitro and in vivo tests
A new drug formulation of the adrenal cortex (AC) inhibitor o,p′-DDD (chloditan) was developed as a solution for i.v. injection… 
1998
1998
[The effect of chloditan on synthetic processes in the adrenal gland cells of newborn piglets].
In experiments with a primary culture of adrenal cells, it has been studied the influence of chloditane, as a specific inhibitor… 
1994
1994
[Effect of chloditan on the changes of activity of glutathione transferase, glutathione reductase and glutathione content in the adrenal glands and liver in rats].
The chloditan (o.p-DDD, mitotane), which causes the destruction of the human and dog adrenal cortex, on the most essential system… 
1990
1990
[The effect of ascorbate, NADPH and chloditan on lipid peroxidation in the adrenal glands of dogs and guinea pigs in vitro].
Lipid peroxidation was studied in dog and guinea pig adrenal cortex homogenates in vitro in presence of ascorbate, NADPH and I-(o… 
1989
1989
[Lipid peroxidation in the liver of dogs and guinea pigs receiving chloditan].
The contents and the rates of the formation of lipid peroxides in the liver homogenates were studied. Dogs and guinea pigs were… 
1984
1984
Finding optimal conditions for preparation of chloditan
4-Hydroxy-2-methyl-7-formylpyrrolo[3,2-d]pyrimidine (VI). A l.l-ml (0.012 mole) sample of POCI3 was added dropwise to i0 ml of… 
1984
1984
[Dynamics of beta-lipotropin and beta-endorphin levels in Itsenko-Cushing disease patients being treated with the antiserotonin preparation cyproheptadine (peritol) and chloditan].
The authors provide the data on the changes in the blood content of opioid neuropeptides in patients with Icenko-Cushing's… 
1983
1983
[Dynamics of secretion of hypothalamo-hypophyseal system hormones in Itsenko-Cushing disease as affected by combination therapy].
The results are presented of the studies on corticotropin, cortisol, beta-lipotropin, beta-endorphine, somatotropin, somatostatin… 
1982
1982
[Effectiveness of a Soviet human somatotropin in treating hypothalamo-hypophyseal nanism].
1976
1976
[Blood levels of ACTH and cortisol in patients with Itsenko-Cushing disease treated with chloditan].
The authors present the results of examination of the content of ACTH and cortizol in the blood of 55 patients with Itsenko… 
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