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Hyaluronan synthases.
Virtually all of the known enzymes utilize one, two, or three substrates to produce one or two products. The hyaluronan (HA) synthase enzyme family is very unusual, and perhaps unique, in that theseExpand
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Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases*
Hyaluronan synthases (HASs) are glycosyltransferases that catalyze polymerization of hyaluronan found in vertebrates and certain microbes. HASs transfer two distinct monosaccharides in differentExpand
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Hyaluronic Acid Production in Bacillus subtilis
ABSTRACT The hasA gene from Streptococcus equisimilis, which encodes the enzyme hyaluronan synthase, has been expressed in Bacillus subtilis, resulting in the production of hyaluronic acid (HA) inExpand
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Identification of the Hyaluronan Receptor for Endocytosis (HARE)*
Rat liver sinusoidal endothelial cells (LECs) express two hyaluronan (HA) receptors, of 175 and 300 kDa, responsible for the endocytic clearance of HA. We have characterized eight monoclonalExpand
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Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.
The hyaluronan (HA) synthase of Group A Streptococci has been identified by transposon mutagenesis and deletion analysis. The genes for the HA synthase and a recently identified UDP-Glc dehydrogenaseExpand
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Topological Organization of the Hyaluronan Synthase fromStreptococcus pyogenes *
Since we first reported (DeAngelis, P. L., Papaconstantinou, J., and Weigel, P. H. (1993) J. Biol. Chem. 268, 19181–19184) the cloning of the hyaluronan (HA) synthase from Streptococcus pyogenesExpand
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Glycans as endocytosis signals: the cases of the asialoglycoprotein and hyaluronan/chondroitin sulfate receptors.
  • P. Weigel, J. Yik
  • Biology, Medicine
  • Biochimica et biophysica acta
  • 19 September 2002
Animal cells internalize specific extracellular macromolecules (ligands) by using specialized cell surface receptors that operate through a complex and highly regulated process known asExpand
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Digestion products of the PH20 hyaluronidase inhibit remyelination
Oligodendrocyte progenitor cells (OPCs) recruited to demyelinating lesions often fail to mature into oligodendrocytes (OLs) that remyelinate spared axons. The glycosaminoglycan hyaluronan (HA)Expand
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Functional Characteristics and Catalytic Mechanisms of the Bacterial Hyaluronan Synthases
  • P. Weigel
  • Biology, Medicine
  • IUBMB life
  • 1 October 2002
The first gene for a glycosaminoglycan synthase to be cloned was the hyaluronan (HA) synthase from S. pyogenes, which we reported in 1993. Since then, at least 20 bacterial, viral, or eukaryotic HAExpand
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The Hyaluronan Receptor for Endocytosis (HARE) Activates NF-κB-mediated Gene Expression in Response to 40–400-kDa, but Not Smaller or Larger, Hyaluronans*
Background: HARE mediates systemic clearance of hyaluronan (HA), which turns over continuously in tissues. Results: HARE uptake of 40–400-kDa, but not larger or smaller, HA stimulated NF-κBExpand
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