FAQ

Mitolactol

Known as: 6-dibromodideoxydulcitol, 6-dibromodulcitol, Dibromdicil 
A synthetic derivative of hexitol with antineoplastic and radiosensitizing properties. Mitolactol alkylates DNA via actual or derived epoxide groups… (More)

Topic mentions per year

Topic mentions per year

1956-2017
010020019562016

Related topics

Related topics

18 relations

Narrower (5)

1,2-anhydro-6-bromogalactitolDoxorubicin HydrochlorideElobromolNSC-104800
(More)

Broader (1)

Antineoplastic Agents, Alkylating
DAVTH protocolIn Bloodadministration & dosageagonists
(More)

Related mentions per year

Related mentions per year

1946-2018
19401960198020002020
Mitolactol
agonists
chemical synthesis
Doxorubicin Hydrochloride
standards characteristics
fluorouracil/methotrexate/mitolactol/prednisone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease
Key factors contributing to early stages of atherosclerosis and plaque development include the pro-inflammatory cytokines… (More)
Is this relevant?
Highly Cited
2014
Highly Cited
2014
Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
Transcription factor (TF) DNA sequence preferences direct their regulatory activity, but are currently known for only ∼1% of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2008
Highly Cited
2008
DBD––taxonomically broad transcription factor predictions: new content and functionality
DNA-binding domain (DBD) is a database of predicted sequence-specific DNA-binding transcription factors (TFs) for all publicly… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2007
Highly Cited
2007
Comparison of Direct and Indirect Effects of Non-Thermal Atmospheric Pressure Plasma on Bacteria and Mechanisms of Such Interaction
Summary form only given. Non-thermal plasmas are already well-known for their sterilization ability; however, the mechanisms of… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Computational approaches for predicting the biological effect of p53 missense mutations: a comparison of three sequence analysis based methods
Prediction of the biological effect of missense substitutions has become important because they are often observed in known or… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The BRCA2 homologue Brh2 nucleates RAD51 filament formation at a dsDNA-ssDNA junction.
The BRCA2 tumour suppressor is essential for the error-free repair of double-strand breaks (DSBs) in DNA by homologous… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The roles of auxin response factor domains in auxin-responsive transcription.
Auxin response factors (ARFs) are transcription factors that bind to TGTCTC auxin response elements in promoters of early auxin… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2003
Highly Cited
2003
The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation.
Sperm DNA fragmentation is being increasingly recognized as an important cause of infertility. We herein describe the Sperm… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • table 3
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Tamoxifen activation of the estrogen receptor/AP-1 pathway: potential origin for the cell-specific estrogen-like effects of antiestrogens.
We find that tamoxifen is a potent activator of estrogen receptor (ER)- mediated induction of promoters regulated by AP-1 sites… (More)
Is this relevant?
Highly Cited
1988
Highly Cited
1988
The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer.
Extracts containing wild-type or mutant human estrogen receptor (ER) have been used to study the binding of ER to its responsive… (More)
Is this relevant?