Mitofusin-2

Known as: EC 3.6.5.-, Mitochondrial Assembly Regulatory Factor, Transmembrane GTPase MFN2 
Mitofusin-2 (757 aa, ~86 kDa) is encoded by the human MFN2 gene. This protein is involved in both mitochondrial fusion and GTP hydrolysis.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Mitochondria play a key role in maintaining cellular metabolic homeostasis. These organelles have a high plasticity and are… (More)
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Highly Cited
2012
Highly Cited
2012
Molecular studies examining the impact of mitochondrial morphology on the mammalian heart have previously focused on dynamin… (More)
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Highly Cited
2011
Highly Cited
2011
Mitofusin-2 (Mfn-2) is a dynamin-like protein that is involved in the rearrangement of the outer mitochondrial membrane. Research… (More)
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2011
2011
Mitochondrial GTPase mitofusin-2 gene (Mfn2) is a novel gene characterised as a cell proliferation inhibitor. Mfn2 protein over… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE Type 2 diabetes is associated with insulin resistance and skeletal muscle mitochondrial dysfunction. We have found that… (More)
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2009
2009
Communication between endoplasmic reticulum (ER) and mitochondria is crucial for Ca(2+) homeostasis, lipid biosynthesis and… (More)
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Highly Cited
2007
Highly Cited
2007
An inexorable loss of terminally differentiated heart muscle cells is a crucial causal factor for heart failure. Here, we have… (More)
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Highly Cited
2005
Highly Cited
2005
The primary gene mutated in Charcot-Marie-Tooth type 2A is mitofusin-2 (Mfn2). Mfn2 encodes a mitochondrial protein that… (More)
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2005
2005
Mitofusin-2 (Mfn2) is an essential component of mitochondrial fusion machinery, but its molecular mechanism of action is not… (More)
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Highly Cited
2003
Highly Cited
2003
In many cells and specially in muscle, mitochondria form elongated filaments or a branched reticulum. We show that Mfn2… (More)
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