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Mitofusin-2

Known as: EC 3.6.5.-, Mitochondrial Assembly Regulatory Factor, Transmembrane GTPase MFN2 
Mitofusin-2 (757 aa, ~86 kDa) is encoded by the human MFN2 gene. This protein is involved in both mitochondrial fusion and GTP hydrolysis.
National Institutes of Health

Related topics

Related topics

8 relations
Enzyme GeneGTP BindingGuanosine Triphosphate PhosphohydrolasesHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MicroRNA-214 Affects Fibroblast Differentiation of Adipose-Derived Mesenchymal Stem Cells by Targeting Mitofusin-2 during Pelvic Floor Dysfunction in SD Rats with Birth Trauma
Background/Aims: This study investigated whether microRNA-214 (miR-214) targets mitofusin-2 (Mfn2) in the process of fibroblast… 
2015
2015
Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma
Abstract Mitofusin-2 (MFN2) is a mitochondrial protein associated with mitochondrial fusion process. It was initially identified… 
2015
2015
Pro-apoptotic and anti-proliferative effects of mitofusin-2 via PI3K/Akt signaling in breast cancer cells.
The mitochondrial GTPase mitofusin-2 (Mfn2) gene is a novel gene characterized as a cell proliferation inhibitor. Mfn2 has… 
2014
2014
Activation of AMPKα2 Is Not Crucial for Mitochondrial Uncoupling-Induced Metabolic Effects but Required to Maintain Skeletal Muscle Integrity
Transgenic (UCP1-TG) mice with ectopic expression of UCP1 in skeletal muscle (SM) show a phenotype of increased energy… 
2013
2013
A Novel 5'-Uncoding Region -1248 A>G Variation of Mitofusin-2 Gene Is Associated with Hypertension in Chinese
Purpose Mitofusin2 gene (Mfn2, also named Hyperplasia suppressive gene, HSG) is very important in the origin and development of… 
2012
2012
Modulating Mitochondrial Fission to Lower Diabetic Oxidative Stress
Mitochondria are at the crossroads of energy metabolism, and they play a major role in the regulation of cell life and death… 
2012
2012
Hepatitis B virus X protein inhibits p53-mediated upregulation of mitofusin-2 in hepatocellular carcinoma cells.
Highly Cited
2011
Highly Cited
2011
Anti-tumour efficacy of mitofusin-2 in urinary bladder carcinoma
Mitochondrial GTPase mitofusin-2 gene (Mfn2) is a novel gene characterised as a cell proliferation inhibitor. Mfn2 protein over… 
2008
2008
Effects of mitofusin-2 gene on cell proliferation and chemotherapy sensitivity of MCF-7
SummaryIn order to evaluate the effect of mitofusin-2 gene (mfn2) on proliferation and chemotherapy sensitivity of human breast… 
Review
2007
Review
2007
[Mutations in the mitofusin 2 gene are the most common cause of Charcot-Marie-Tooth type 2 disease].
In contrast to Charcot-Marie-Tooth type 1 disease (CMT1), which is most commonly caused by 17p11.2-p12 duplication (in 70% of… 
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