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Mitofusin-2

Known as: EC 3.6.5.-, Mitochondrial Assembly Regulatory Factor, Transmembrane GTPase MFN2 
Mitofusin-2 (757 aa, ~86 kDa) is encoded by the human MFN2 gene. This protein is involved in both mitochondrial fusion and GTP hydrolysis.
National Institutes of Health

Related topics

Related topics

8 relations
Enzyme GeneGTP BindingGuanosine Triphosphate PhosphohydrolasesHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
MicroRNA-214 Affects Fibroblast Differentiation of Adipose-Derived Mesenchymal Stem Cells by Targeting Mitofusin-2 during Pelvic Floor Dysfunction in SD Rats with Birth Trauma
Background/Aims: This study investigated whether microRNA-214 (miR-214) targets mitofusin-2 (Mfn2) in the process of fibroblast… 
2016
2016
Transcriptional profiling revealed the anti-proliferative effect of MFN2 deficiency and identified risk factors in lung adenocarcinoma
Mitofusin-2 (MFN2) was initially identified as a hyperplasia suppressor in hyper-proliferative vascular smooth muscle cells… 
2015
2015
Mitofusin-2 over-expresses and leads to dysregulation of cell cycle and cell invasion in lung adenocarcinoma
Abstract Mitofusin-2 (MFN2) is a mitochondrial protein associated with mitochondrial fusion process. It was initially identified… 
2015
2015
Mitofusin-2 in cardiac diseases
Mitochondria are highly dynamic organelles with constant fusion and fission. Mitofusin-2( Mfn2) is widely distributed on the… 
2013
2013
A Novel 5'-Uncoding Region -1248 A>G Variation of Mitofusin-2 Gene Is Associated with Hypertension in Chinese
Purpose Mitofusin2 gene (Mfn2, also named Hyperplasia suppressive gene, HSG) is very important in the origin and development of… 
2013
2013
Spectrum and frequencies of mutations in the MFN2 gene and its phenotypical expression in Czech hereditary motor and sensory neuropathy type II patients.
The axonal type of Charcot‑Marie‑Tooth (CMT) disorders is genetically heterogeneous, therefore the causal mutation is unlikely to… 
2012
2012
Modulating Mitochondrial Fission to Lower Diabetic Oxidative Stress
Mitochondria are at the crossroads of energy metabolism, and they play a major role in the regulation of cell life and death… 
2009
2009
Expression of mitofusin-2 in non-small-cell lung cancer and its clinical significance
Objective:To investigate the expressions of Mfn2(mitofusin 2) in non-small-cell lung cancer(NSCLC) tissues and non-cancerous lung… 
2008
2008
Effects of mitofusin-2 gene on cell proliferation and chemotherapy sensitivity of MCF-7
SummaryIn order to evaluate the effect of mitofusin-2 gene (mfn2) on proliferation and chemotherapy sensitivity of human breast… 
Review
2004
Review
2004
[Role of novel mitochondrial proteins in energy balance].
Mitochondrial activity plays a key role in the control of thermogenesis and energy expenditure in homeothermic organisms… 
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